By Jane Wu
ISBN-10: 3527322027
ISBN-13: 9783527322022
ISBN-10: 3527665439
ISBN-13: 9783527665433
Reflecting the speedy growth within the box, the ebook provides the present realizing of molecular mechanisms of post-transcriptional gene law thereby concentrating on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA enhancing and others, the booklet additionally discusses the serious function of RNA processing for the pathogenesis of quite a lot of human illnesses. The interdisciplinary significance of the subject makes the identify an invaluable source for a large reader team in technology, clinics in addition to pharmaceutical industry.Content:
Chapter 1 The function of Cotranscriptional Recruitment of RNA?Binding Proteins within the upkeep of Genomic balance (pages 1–18): Jennifer A. Aoki and James L. Manley
Chapter 2 Transcription Termination by way of RNA Polymerase II (pages 19–40): Minkyu Kim and Stephen Buratowski
Chapter three Posttranscriptional Gene rules through an Editor: ADAR and its position in RNA modifying (pages 41–81): Louis Valente, Yukio Kawahara, Boris Zinshteyn, Hisashi Iizasa and Kazuko Nishikura
Chapter four Posttranslational amendment of Sm Proteins: various Roles in snRNP meeting and Germ Line Specification (pages 83–116): Graydon B. Gonsalvez and A. Gregory Matera
Chapter five constitution, functionality, and Biogenesis of Small Nucleolar Ribonucleoprotein debris (pages 117–132): Katherine S. Godin and Gabriele Varani
Chapter 6 Mechanistic Insights into Mammalian Pre?mRNA Splicing (pages 133–161): Sebastian M. Fica, Eliza C. Small, Melissa Mefford and Jonathan P. Staley
Chapter 7 Splicing judgements form Neuronal Protein functionality around the Transcriptome (pages 163–180): Jill A. Dembowski and Paula J. Grabowski
Chapter eight Noncoding RNA: the key Output of Gene Expression (pages 181–213): Matthias Harbers and Piero Carninci
Chapter nine Noncoding RNAs, Neurodevelopment, and Neurodegeneration (pages 215–238): Mengmeng Chen, Jianwen Deng, Mengxue Yang, Kun Zhu, Jianghong Liu, Li Zhu and Dr. Jane Y. Wu
Chapter 10 The Evolution of the trendy RNA global (pages 239–252): Ying Chen, Hongzheng Dai and Manyuan lengthy
Read Online or Download Posttranscriptional Gene Regulation: RNA Processing in Eukaryotes PDF
Best bioinformatics books
Information Theory and Evolution - download pdf or read online
This hugely interdisciplinary ebook discusses the phenomenon of lifestyles, together with its starting place and evolution (and additionally human cultural evolution), opposed to the heritage of thermodynamics, statistical mechanics, and knowledge thought. one of the significant issues is the seeming contradiction among the second one legislation of thermodynamics and the excessive measure of order and complexity produced through residing platforms.
Geoffrey S. Ginsburg, Huntington F Willard PhD's Essentials of Genomic and Personalized Medicine PDF
Derived from the excellent two-volume set, Genomic and customized medication additionally edited via Drs. Willard and Ginsburg, this paintings serves the desires of the evolving inhabitants of scientists, researchers, practitioners and scholars which are embracing probably the most promising avenues for advances in prognosis, prevention and therapy of human illness.
Pey-Chang Kent Lin's Logic Synthesis for Genetic Diseases: Modeling Disease PDF
This e-book brings to undergo a physique of common sense synthesis suggestions, with the intention to give a contribution to the research and keep watch over of Boolean Networks (BN) for modeling genetic illnesses akin to melanoma. The authors supply numerous VLSI common sense suggestions to version the genetic affliction habit as a BN, with robust implicit enumeration recommendations.
New PDF release: Electroanalytical Methods Of Biological Materials
This article information modern electroanalytical options of biomolecules and electric phenomena in organic platforms. It provides major advancements in sequence-specific DNA detection for extra effective and low-budget scientific analysis of genetic and infectious illnesses and microbial and viral pathogens.
- Clinical Information Systems: A Component-Based Approach (Health Informatics)
- Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics (Wiley Series in Probability and Statistics)
- Relics of Eden: The Powerful Evidence of Evolution in Human DNA
- From genes to genomes : concepts and applications of DNA technology
- Proteome Research: Concepts, Technology and Application
Additional info for Posttranscriptional Gene Regulation: RNA Processing in Eukaryotes
Sample text
L. (2001) Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. Mol. Cell, 7, 1013–1023. L. (2002) EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3′ end cleavage of nascent transcripts. Chromosoma, 111, 1–12. , and Keller, W. (2003) Independent functions of yeast Pcf11p in pre-mRNA 3′ end processing and in transcription termination. , 22, 2167–2177. S. (2005) CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3′-end processing factor, Pcf11.
B. , and Shenk, T. (1987) A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc. Natl. Acad. Sci. , 84, 8306–8310. 2 Connelly, S. L. (1988) A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. , 2, 440–452. , and Buratowski, S. (2000) Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription.
2006) Ig class switching: targeting the recombinational mechanism. Curr. Opin. , 18, 249–254. , and Maizels, N. (2005) AID binds to transcription-induced structures in c-MYC that map to regions associated with translocation and hypermutation. Oncogene, 24, 5791–5798. W. (2011) The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell, 144, 353–363. R. (2005) Fine-structure analysis of activationinduced deaminase accessibility to class switch region R-loops.
Posttranscriptional Gene Regulation: RNA Processing in Eukaryotes by Jane Wu
by Edward
4.4