By Geoffrey S. Ginsburg, Huntington F Willard PhD
ISBN-10: 0123749344
ISBN-13: 9780123749345
Derived from the great two-volume set, Genomic and custom-made drugs additionally edited through Drs. Willard and Ginsburg, this paintings serves the desires of the evolving inhabitants of scientists, researchers, practitioners and scholars which are embracing probably the most promising avenues for advances in prognosis, prevention and remedy of human disorder. From rules, technique and translational ways to genome discoveries and scientific purposes, necessities of Genomic and customized drugs could be a precious source for varied execs and scholars throughout clinical disciplines, together with human genetics and genomics, oncology, neuroscience, gene treatment, molecular medication, pharmacology, and biomedical sciences. Updates in regards to diagnostic trying out, pharmacogenetics, predicting ailment susceptibility, and different very important examine parts in addition to chapters devoted to heart problems, oncology, inflammatory ailment, metabolic affliction, neuropsychiatric disorder, and infectious disorder, current this ebook as an important device for quite a few pros and scholars who're endeavouring into the constructing the various and functional box of genomic and customized drugs. * complete colour all through * comprises contributions on genetic counselling, moral, legal/regulatory, and social matters on the topic of the perform of genomic drugs from leaders within the box * Introductory bankruptcy highlights transformations among custom-made and conventional drugs, promising parts of present study, and demanding situations to include the newest study discoveries and perform * Ancillary fabric comprises case stories and lab questions which spotlight the collaborative method of the technology
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3. 4. 5. 6. 7. 8. 9. 1 Organization,Variation and Expression of the Human Genome DNA Sequencing for the Detection of Human Genome Variation Genome-Wide Association Studies and Genotyping Technologies Copy Number Variation and Human Health DNA Methylation Analysis: Providing New Insight into Human Disease DNA Microarrays in Biological Discovery and Patient Care Proteomics: The Deciphering of the Functional Genome Comprehensive Metabolic Analysis for Understanding of Disease This page intentionally left blank CHAPTER 2 Organization, Variation and Expression of the Human Genome Huntington F.
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102, 10604–10609. , John, E. et al. (2006). Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci USA 103, 14068–14073. , Brown-John, M. et al. (2006). Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation. Am J Hum Genet 79, 500–513. Garrod, A. (1902). The incidence of alkaptonuria: A study in chemical individuality.
2005; International HapMap Consortium, 2003, 2007). Most of the studies to date, however, have been restricted to a small number of populations of Northern European, African and Asian origin used for SNP detection. From these and a large number of earlier studies that examined more populations but for many fewer variants, it has been concluded that some 85–90% of the variation found in our species is shared among different population groups; a relative minority of variants, therefore, are specific to or highly enriched/depleted in genomes from a particular population.
Essentials of Genomic and Personalized Medicine by Geoffrey S. Ginsburg, Huntington F Willard PhD
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