By Priv.-Doz. Dr. med. Peter Kugler (auth.)
ISBN-10: 3540114521
ISBN-13: 9783540114529
ISBN-10: 3642685528
ISBN-13: 9783642685521
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Additional resources for On Angiotensin-Degrading Aminopeptidases in the Rat Kidney
Sample text
APA and APM are demonstrable mainly in these brush borders in the rat and mouse. In the proximal tubule of the male rat, the highest APA activities are localized in the 8 3 segment (subcortical zone) (Figs. 56, 58). Taking as 100% the APA activities in the 8 3 segment of male rats as determined by quantitative histochemical measurements, the APA activities in 8 2 ate approximately 63%, and in 8 1 approximately 14% (Fig. 31). Accordingly, the lowest APA activities in the proximal tubule occur in the 8 1 segment (Fig.
41. The brush borders of the proximal tubule and the "tubule-like cells" of Bowman's capsule (arrows) are APMpositive. No reaction in the glomeruli. ). Bowman's capsule shows the following morphologic differences between adult mice and rats that have a bearing on the histochemical demonstration of enzymes: While in the rat Bowman's capsule has a monolayer squamous epithelium, many Bowman's capsules 38 in the mouse possess isoprismatic to highly prismatic epithelial cells with brush borders ("tubule-like cells"; Von Mollendorf 1930, Helmholz 1935, Hanker et al.
Bowman's capsule shows the following morphologic differences between adult mice and rats that have a bearing on the histochemical demonstration of enzymes: While in the rat Bowman's capsule has a monolayer squamous epithelium, many Bowman's capsules 38 in the mouse possess isoprismatic to highly prismatic epithelial cells with brush borders ("tubule-like cells"; Von Mollendorf 1930, Helmholz 1935, Hanker et al. 1975; Kugler 1981b). According to Crabtree (1940),94% ofthe renal corpuscles in adult male mice and 50% of those in adult females contain an isoprismatic parietal epithelium.
On Angiotensin-Degrading Aminopeptidases in the Rat Kidney by Priv.-Doz. Dr. med. Peter Kugler (auth.)
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