By Dr. Robert F. Schleif
ISBN-10: 0801846730
ISBN-13: 9780801846731
ISBN-10: 0801846749
ISBN-13: 9780801846748
In the 1st variation of Genetics and Molecular Biology, well known researcher and award-winning instructor Robert Schleif produced a different and stimulating textual content that used to be a impressive departure from the normal compendia of evidence and observations. Schleif's approach was once to provide the underlying primary techniques of molecular biology with transparent motives and significant research of well-chosen experiments. the end result was once a concise and useful process that provided scholars a true realizing of the topic. This moment version keeps that helpful approach--with fabric completely up to date to incorporate an built-in therapy of prokaryotic and eukaryotic molecular biology.
Genetics and Molecular Biology is copiously illustrated with two-color line paintings. every one bankruptcy comprises an intensive record of significant references to the first literature, in addition to many leading edge and thought-provoking difficulties on fabric lined within the textual content or on similar subject matters. those aid concentration the student's awareness of various serious concerns. recommendations are supplied for half the problems.
Praise for the 1st edition:
"Schleif's Genetics and Molecular Biology... is a outstanding success. it's a complicated textual content, derived from fabric taught mostly to postgraduates, and should most likely be idea most fitted to budding pros in molecular genetics. In many ways this might be a pity, simply because there's additionally gold the following for the remainder of us... the teachings the following in facing the data explosion in biology are that an oz of intent is worthy a pound of evidence and that, for academic worth, there's not anything to overcome an writer writing approximately stuff he understands from the inside."--Nature.
"Schleif provides a quantitative, chemically rigorous method of reading difficulties in molecular biology. The textual content is exclusive and obviously more suitable to any at present available."--R.L. Bernstein, San Francisco nation University.
"The maximum energy is the author's skill to problem the scholar to get involved and get less than the surface."--Clifford Brunk, UCLA
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Additional resources for Genetics and Molecular Biology
Example text
1. Propose an explanation for the following facts known about E. coli: appreciable volume exists between the inner membrane and the peptidoglycan layer; the inner membrane is too weak to withstand the osmotic pressure of the cytoplasm and must be supported by a strong, rigid structure; and no spacers have been discovered that could hold the inner membrane away from the peptidoglycan layer. 2. If the E. coli interior were water at pH 7, how many H+ ions would exist within the cell at any instant?
Where two DNA duplexes cross, gyrase, with the consumption of an ATP molecule, can permit the duplex lying below to be cut, to pass the first, and to be rejoined. 14 The strand inversion pathway as applied by DNA topoisomerase I in which a region of DNA is melted and one strand is broken, passed by the other, and rejoined. strand crossing is to occur (Fig. 14). These are known as sign-inversion pathways because they change the sign of the linking number that is contributed by a point of crossing of the two DNA strands.
X-ray fiber diffraction studies of DNA in different salts and at different humidities yield forms in which the repeats vary from 9 1⁄3 base pairs per turn to 11 base pairs per turn. 1). More recent diffraction studies of crystals of short oligonucleotides of specific sequence have revealed substantial base to base variation in the twist from one base to the next. 63 Diameter 23 19 19 18 whether it is meaningful to speak of the various forms of the DNA. Nonetheless, on average, natural DNA, that is DNA with all four bases represented in random sequence over short distances, has a conformation most closely represented by B-form DNA.
Genetics and Molecular Biology by Dr. Robert F. Schleif
by Ronald
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