Category: Bioinformatics

By Roustem N. Miftahof, Hong Gil Nam

ISBN-10: 364221472X

ISBN-13: 9783642214721

The complexity of human uterine functionality and rules is without doubt one of the nice wonders of nature and represents a frightening problem to resolve. This e-book is devoted to the biomechanical modeling of the gravid human uterus and offers an instance of the applying of the mechanics of solids and the idea of sentimental shells to discover clinical difficulties of work and supply. After a quick assessment of the anatomy, body structure and biomechanics of the uterus, the authors concentration almost always on electromechanical wave procedures, their starting place, dynamics, and neuroendocrine and pharmacological modulations. within the final bankruptcy purposes, pitfalls and difficulties with regards to modeling and laptop simulations of the pregnant uterus and pelvic ground buildings are mentioned. a set of routines is further on the finish of every bankruptcy to assist readers with self-evaluation.

The publication serves as a useful resource of data for researchers, teachers and complex undergraduate and graduate scholars drawn to structures biology, utilized arithmetic and biomedical engineering.

By Sam Thiagalingam

ISBN-10: 0511979819

ISBN-13: 9780511979811

ISBN-10: 0521493390

ISBN-13: 9780521493390

ISBN-10: 1316247082

ISBN-13: 9781316247082

With over two hundred forms of melanoma clinically determined up to now, researchers across the world were pressured to quickly replace their knowing of the biology of melanoma. actually, merely the learn of the fundamental mobile tactics, and the way those are altered in melanoma cells, can finally offer a history for rational cures. Bringing jointly the state of the art contributions of overseas specialists, platforms Biology of melanoma proposes an final examine target for the total medical group: exploiting platforms biology to generate in-depth wisdom in keeping with blueprints which are precise to every kind of melanoma. Readers are supplied with a practical view of what's recognized and what's but to be exposed at the aberrations within the primary organic procedures, deregulation of significant signaling networks, changes in significant cancers and the thoughts for utilizing the clinical wisdom for powerful analysis, diagnosis and drug discovery to enhance public well-being

By Andres Kriete, Roland Eils

ISBN-10: 012088786X

ISBN-13: 9780120887866

Platforms Biology is worried with the quantitative learn of advanced biosystems on the molecular, mobile, tissue, and platforms scales. Its concentration is at the functionality of the procedure as a complete, instead of on person components. This intriguing new enviornment applies mathematical modeling and engineering how you can the examine of organic structures. This publication is the 1st of its style to target the newly rising box of platforms biology with an emphasis on computational methods. The paintings covers new suggestions, tools for info garage, mining and data extraction, opposite engineering of gene and metabolic networks, in addition to modelling and simulation of multi-cellular structures. critical subject matters comprise ideas for predicting organic houses and techniques for elucidating structure-function relationships.

By Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole

ISBN-10: 3662463059

ISBN-13: 9783662463055

This e-book presents an creation to the most recent gene mapping thoughts and their functions in biomedical examine and evolutionary biology. It specifically highlights the advances made in large-scale genomic sequencing. result of stories that illustrate how the recent techniques have more desirable our figuring out of the genetic foundation of advanced phenotypes together with multifactorial illnesses (e.g., heart problems, kind 2 diabetes, and obesity), anatomic features (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human mind constitution and nonhuman primate habit) are presented.

Topics lined contain linkage and organization equipment, gene expression, reproduction quantity version, next-generation sequencing, comparative genomics, inhabitants constitution, and a dialogue of the Human Genome undertaking. extra incorporated are discussions of using statistical genetic and genetic epidemiologic suggestions to decipher the genetic structure of standard and disease-related advanced phenotypes utilizing info from either people and non-human primates.

By John R. Smythies and Ronald J. Bradley (Eds.)

ISBN-10: 0080857647

ISBN-13: 9780080857640

ISBN-10: 0123668301

ISBN-13: 9780123668301

Released due to the fact that 1959, this serial offers in-depth reports of key themes in neuroscience, from molecules to behaviour. The serial remains keenly atuned to contemporary advancements in the course of the contributions of firstclass specialists within the many fields of neuroscience. Neuroscientists in addition to clinicians, psychologists, physiologists and pharmacoloists will locate this serial an integral addition to their library.

By Larry A. Sklar

ISBN-10: 0195152344

ISBN-13: 9780195152340

Move cytometry is a delicate and quantitative platform for the size of particle fluorescence. In circulate cytometry, the debris in a pattern circulation in unmarried dossier via a concentrated laser beam at charges of hundreds of thousands to hundreds of thousands of debris in line with moment. in the course of the time each one particle is within the laser beam, at the order of ten microseconds, a number of fluorescent dyes linked to that particle are excited. The fluorescence emitted from every one particle is amassed via a microscope goal, spectrally filtered, and detected with photomultiplier tubes. move cytometry is uniquely in a position to the suitable and quantitative molecular research of genomic series info, interactions among purified biomolecules and mobile functionality. mixed with automatic pattern dealing with for elevated pattern throughput, those positive factors make move cytometry a flexible platform with functions at many phases of drug discovery. frequently, the debris studied are cells, particularly blood cells; movement cytometry is used commonly in immunology. This quantity indicates how circulation cytometry is built-in into sleek biotechnology, facing problems with throughput, content material, sensitivity, and excessive throughput informatics with purposes in genomics, proteomics and protein-protein interactions, drug discovery, vaccine improvement, plant and reproductive biology, pharmacology and toxicology, cell-cell interactions and protein engineering.

By Douglas W. Smith

ISBN-10: 0080925960

ISBN-13: 9780080925967

The result of todays genome initiatives promise huge, immense scientific and agricultural advantages and aspect to a brand new predictive method of the behavior of destiny examine in biology. Biocomputing: Informatics and Genome Projects represents a survey of the wishes and ambitions of genome initiatives as of the early Nineties. It presents the basis essential to comprehend genome-related informatics, together with computational and database garage ambitions. The ebook covers 4 common components: automatic laboratory notebooks, nucleic acid series research, protein constitution, and database actions.

By Jiapu Zhang

ISBN-10: 9401773173

ISBN-13: 9789401773171

ISBN-10: 9401773181

ISBN-13: 9789401773188

This monograph is the 1st easy-to-read-and-understand publication on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) structures. It allows researchers to determine what's an important to the conformational swap from general mobile prion protein (PrP^C) to diseased infectious prions (PrP^Sc), utilizing MD and MM thoughts. As we know, prion ailments, as a result of the body's personal proteins, are normally deadly and hugely infectious neurodegenerative ailments effecting people and just about all animals for an incredible public well-being challenge. Prion includes no nucleic acids and it's a misshapen or conformation-changed protein that acts like an infectious agent; therefore prion illnesses are referred to as “protein structural conformational” diseases.

PrP^C is main in α-helices yet PrP^Sc are wealthy in β-sheets within the shape as amyloid fibrils; so very amenable to be studied via MD recommendations. via MD, experiences at the protein buildings and the structural conversion are vitally important for revealing secrets and techniques of prion ailments and for structure-based drug layout or discovery. Rabbits, canine, horses and buffaloes are suggested to be the few low susceptibility species to prion ailments; this book's MD stories on those species are in actual fact useful to appreciate the mechanism underlying the resistance to prion illnesses. PrP(1-120) often has no transparent molecular buildings; this booklet additionally experiences this unstructured sector via MD and particularly MM thoughts from the worldwide optimization element of view.

This booklet is perfect for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, fabrics technological know-how and engineering, utilized arithmetic and theoretical physics, details expertise, operations study, biostatistics, and so forth. As an obtainable creation to those fields, this ebook can be excellent as a educating fabric for students.

By Martin Zacharias

ISBN-10: 184816338X

ISBN-13: 9781848163386

ISBN-10: 1848163398

ISBN-13: 9781848163393

Given the great growth completed in elucidating protein–protein complicated buildings and within the box of protein interplay modeling, there's nice call for for a e-book that provides researchers/students a finished evaluation of the sphere. This e-book does simply that. It specializes in what should be discovered approximately protein–protein interactions from the research of protein–protein complicated constructions and interfaces. What are the riding forces for protein–protein organization? How do we extract the mechanism of particular reputation from learning protein–protein interfaces? How can this data be used to foretell and layout protein–protein interactions (interaction areas and intricate structures)? What tools are at present hired to layout protein–protein interactions, and the way do we impact protein–protein interactions by way of mutagenesis and small-molecule medicinal drugs or peptide mimetics? The booklet includes approximately 15 assessment chapters, written by way of specialists, at the characterization of protein–protein interfaces, constitution choice of protein complexes (by Nmr and X-ray), idea of protein–protein binding, dynamics of protein interfaces, bioinformatics the right way to are expecting interplay areas, and prediction of protein–protein complicated buildings (docking and homology modeling of complexes, etc.) and layout of protein–protein interactions. It serves as a bridge among studying/analyzing protein–protein advanced constructions (interfaces), predicting interactions, and influencing/designing interactions.

By Ludmila V. Yakushevich

ISBN-10: 3527404171

ISBN-13: 9783527404179

The 1st version of this booklet used to be the 1st at the physics of DNA to head past the straightforward (simplified) 'linear' process, and it has on the grounds that been chanced on that the inclusion of nonlinear results results in a considerably more desirable interpretation of experimental information. This new version clearly keeps this procedure, yet has been thoroughly revised, up-to-date and accelerated to hide fresh advancements. starting with introductory chapters on DNA constitution and dynamics, the ebook additionally encompasses a comparability among linear and nonlinear techniques to the DNA molecule, a bankruptcy dedicated to the records of nonlinear excitations of DNA, and examples for the translation of experimental information at the dynamics of DNA when it comes to nonlinear thought. crucial analyzing for researchers in biophysics and nonlinear physics, permitting biologists, chemists and physicists to proceed constructing new and more suitable suggestions of investigating the DNA molecule.