By Roustem N. Miftahof, Hong Gil Nam
The complexity of human uterine functionality and rules is without doubt one of the nice wonders of nature and represents a frightening problem to resolve. This e-book is devoted to the biomechanical modeling of the gravid human uterus and offers an instance of the applying of the mechanics of solids and the idea of sentimental shells to discover clinical difficulties of work and supply. After a quick assessment of the anatomy, body structure and biomechanics of the uterus, the authors concentration almost always on electromechanical wave procedures, their starting place, dynamics, and neuroendocrine and pharmacological modulations. within the final bankruptcy purposes, pitfalls and difficulties with regards to modeling and laptop simulations of the pregnant uterus and pelvic ground buildings are mentioned. a set of routines is further on the finish of every bankruptcy to assist readers with self-evaluation.
The publication serves as a useful resource of data for researchers, teachers and complex undergraduate and graduate scholars drawn to structures biology, utilized arithmetic and biomedical engineering.
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Additional info for Biomechanics of the Gravid Human Uterus
8 mN/cm. A simultaneous elevation in the concentration of extracellular potassium and calcium ions the membrane potential at À18 mV. 4). Ã A gradual reduction of Kþ hyperpolarizes the fasciculus, V r ¼ À70 and À 0 88 ðmV) (Fig. 5). 037 Hz. Concurrent multiple discharges of a pacemaker evoke the production of spikes of an average amplitude of 60 ÂmV at Ã a ¼ frequency of ~6 Hz. There is a weakening of the calcium influx, max Ca2þ i 0:25 and 0:18 mM, and tension, T a ¼ 4:5 and 2:2 ðmN=cmÞ. 0 Time (min) Fig.
2). 72 mM. The myometrium undergoes tonic contraction, T a ¼ 23:75 mN/cm:. A concurrent electrical stimulation of the myofiber evokes ion currents of f s intensities: I~Ca ¼ 1:3; I~Ca ¼ 0:61; I~K1 ¼ 0:62; I~CaÀK ¼ 1:63; I~Cl ¼ 1:89ðnAÞ, and a transient production of a burst of high-frequency, n ¼ 6 Hz, action potentials of amplitude 53 mV. The fast T-type Ca2+ current Â Ã provides the main influx ¼ 0:62 mM is recorded. of intracellular calcium during which max Ca2þ i The fasciculus generates the active force, T a ¼ 20:7 mN/cm.
Traces have a diagnostic value and help decide on rational therapeutic management. The inverse problem in electromyography and magnetography is the reconstruction of underlying cellular and subcellular mechanisms. Could that be done? 9. By what principle could one possibly judge a model of the gravid human uterus as biologically plausible and clinically valuable? Chapter 3 A Dynamic Model of the Fasciculus The further a mathematical theory is developed, the more harmoniously and uniformly does its construction proceed, and unsuspected relations are disclosed between hitherto separated branches of the science.
Biomechanics of the Gravid Human Uterus by Roustem N. Miftahof, Hong Gil Nam