Category: Bioinformatics

By Volker Knoop

ISBN-10: 3827419832

ISBN-13: 9783827419835

Gene, Genome und Sequenzen auf der einen Seite, Algorithmen, desktop und Informatik auf der anderen - sie üben Faszination aus, halten aber viele Interessierte auf respektvolle Distanz. Die Schnittstelle der Bereiche ist mit dem modernen Begriff Bioinformatik belegt. In der Tat hat die Synthese von zwei unabhängigen Disziplinen selten so viele faszinierende neue Einsichten geliefert. Eine spannende Teildisziplin der Bioinformatik ist die Molekulare Phylogenetik, deren Ziel die Rekonstruktion von Stammbäumen aus molekularen Daten ist: desktop, moderne Molekularbiologie und Kladistik haben der etwas angestaubten biologischen Systematik und Taxonomie eine ungeahnte Renaissance verschafft. Der Einstieg in beide Welten gleichzeitig - Molekularbiologie und Phylogenetik - warfare nicht unbedingt einfach. Hier schloss „Gene und Stammbäume" 2006 eine Lücke. Die zweite Auflage behält das bewährte Konzept bei, ist aber inhaltlich um zwei Kapitel erweitert, die den neuesten traits unter anderem bei Bayesianischen Ansätzen Rechnung tragen. Einführende Kapitel über Molekularbiologie, Evolution, Taxonomie und Kladistik ermöglichen je nach Wissenshintergrund einen leichten Zugang zur Molekularen Phylogenetik. Den besonders schnellen Einstieg erlaubt ein spezielles Kapitel über den Weg von der Sequenz zum Stammbaum ohne Umwege oder info. Wer es genauer wissen will, bekommt detaillierte Einführungen in die wichtigen methodischen Ansätze: Parsimonie, Distanzverfahren, greatest probability und Bayesianische Verfahren. Speziellere Kapitel widmen sich neuen Methoden für stammbaumbasierte statistische assessments, Supertrees, Analysen von Substitutionsraten, molekularer Datierung und vielem mehr. Alles wird palms on anhand von nachvollziehbaren Beispielen mit der gängigen software program besprochen, die aus dem web bezogen werden kann. Das Buch bietet so eine ideale stability zwischen Theorie und Praxis. Es hat zahlreiche Illustrationen, bietet am Ende der Kapitel Hinweise zum Weiterlesen und schließt mit einem Glossar und einem umfangreichen Index.

By V. G. Levitsky, A. V. Katokhin, O. A. Podkolodnaya, D. P. Furman (auth.), Nikolay Kolchanov, Ralf Hofestaedt (eds.)

ISBN-10: 1441971521

ISBN-13: 9781441971524

ISBN-10: 147574613X

ISBN-13: 9781475746136

Bioinformatics of Genome legislation and Structurecovers:

-regulatory genomic sequences: databases, wisdom bases, laptop research, modeling, and popularity;
-large-scale genome research and useful annotation;
-gene constitution detection and prediction;
-comparative and evolutionary genomics;
-computer research of genome polymorphism and evolution; computing device research and modeling of transcription, splicing, and translation; structural computational biology: structure-function association of genomic DNA, RNA, and proteins;
-gene networks, sign transduction pathways, and genetically managed metabolic pathways: rules of association, operation, and evolution;
-data warehousing, wisdom discovery and knowledge mining; and,
-analysis of simple styles of genome operation, association, and evolution.

The facts offered can be utilized whereas fixing a variety of difficulties, either uncomplicated and utilized, in quite a few instructions of molecular biology, molecular genetics, biotechnology, pharmacogenetics, pharmacology, and adjoining fields of drugs, veterinary, and agrobiology.

By Gary B. Fogel

ISBN-10: 0470105267

ISBN-13: 9780470105269

ISBN-10: 0470199083

ISBN-13: 9780470199084

Combining biology, computing device technology, arithmetic, and information, the sphere of bioinformatics has turn into a scorching new self-discipline with profound affects on all elements of biology and commercial program. Now, Computational Intelligence in Bioinformatics deals an advent to the subject, overlaying the main appropriate and well known CI tools, whereas additionally encouraging the implementation of those tips on how to readers' study.

By Gautam B. Singh

ISBN-10: 3319114034

ISBN-13: 9783319114033

This e-book deals accomplished assurance of all of the middle themes of bioinformatics, and comprises useful examples accomplished utilizing the MATLAB bioinformatics toolbox™. it really is basically meant as a textbook for engineering and machine technological know-how scholars attending complex undergraduate and graduate classes in bioinformatics and computational biology. The publication develops bioinformatics options from the floor up, beginning with an introductory bankruptcy on molecular biology and genetics. This bankruptcy will allow actual technology scholars to totally comprehend and relish the last word targets of utilising the rules of data know-how to demanding situations in organic facts administration, series research, and platforms biology. the 1st a part of the ebook additionally features a survey of latest organic databases, instruments that experience turn into crucial in today’s biotechnology learn. the second one a part of the e-book covers methodologies for retrieving organic info, together with basic algorithms for series comparability, scoring, and settling on evolutionary distance. the main target of the 3rd half is on modeling organic sequences and styles as Markov chains. It provides key ideas for studying and looking out for sequences of vital motifs and biomarkers. The final a part of the ebook, devoted to platforms biology, covers phylogenetic research and evolutionary tree computations, in addition to gene expression research with microarrays. briefly, the e-book deals the right hands-on reference advisor to the sphere of bioinformatics and computational biology.

By Maurice V. Aldridge

ISBN-10: 3110129574

ISBN-13: 9783110129571

A contribution to the advance of a common concept of that means, utilizing mathematical or Montague semantics, a noncalculative strategy interested by the formal modelling of language. reports the mandatory arithmetic, common sense, and linguistics required to appreciate the remedy; then discusses vagu

By Andrei L. Osterman, Svetlana Y. Gerdes

ISBN-10: 1588293785

ISBN-13: 9781588293787

ISBN-10: 1597453218

ISBN-13: 9781597453219

This ebook features a accomplished choice of experimental and computational suggestions and strategies for microbial genome-scale essentiality stories, constructed and provided through the prime teams within the box. It comprises distinctive description of the tactics, dialogue of strength problems and screw ups. All protocols keep on with the winning tools in Molecular Biology™ sequence structure.

By Francisco Ortuño, Ignacio Rojas

ISBN-10: 3319164791

ISBN-13: 9783319164793

ISBN-10: 3319164805

ISBN-13: 9783319164809

The quantity set LNCS 9043 and 9044 constitutes the refereed lawsuits of the 3rd overseas convention on Bioinformatics and Biomedical Engineering, IWBBIO 2015, held in Granada, Spain, in April 2015.
The one hundred thirty five papers awarded have been conscientiously reviewed and chosen from 268 submissions. The scope of the convention spans the subsequent parts: bioinformatics for healthcare and illnesses, biomedical engineering, biomedical snapshot research, biomedical sign research, computational genomics, computational proteomics, computational platforms for modelling organic strategies, eHealth, subsequent new release sequencing and series research, quantitative and structures pharmacology, Hidden Markov version (HMM) for organic series modeling, advances in computational intelligence for bioinformatics and biomedicine, instruments for subsequent new release sequencing info research, dynamics networks in method medication, interdisciplinary puzzles of measurements in organic structures, organic networks, excessive functionality computing in bioinformatics, computational biology and computational chemistry, advances in drug discovery, and ambient intelligence for bioemotional computing.

By Judith L. Campbell, Paul Modrich

ISBN-10: 012182814X

ISBN-13: 9780121828141

This quantity emphasizes the intracellular results of DNA harm, describing strategies for research of checkpoint responses, DNA fix in vivo, replication fork come upon of DNA harm, in addition to organic tools for research of mutation construction and chromosome rearrangements. It additionally describes molecular equipment for research of a couple of genome upkeep actions together with DNA ligases, helicases, and single-strand binding proteins. *Part B of a 2-part series*Addresses DNA upkeep enzymes*Discusses harm signaling*Presents In vivo research of DNA repair*Covers mutation and chromosome rearrangements

By Pierre Baldi, Sören Brunak

An unheard of wealth of information is being generated by way of genome sequencing initiatives and different experimental efforts to figure out the constitution and serve as of organic molecules. The calls for and possibilities for reading those information are increasing quickly. Bioinformatics is the improvement and alertness of laptop equipment for administration, research, interpretation, and prediction, in addition to for the layout of experiments. computing device studying methods (e.g., neural networks, hidden Markov types, and trust networks) are perfect for parts the place there's a lot of information yet little thought, that's the location in molecular biology. The aim in computer studying is to extract precious info from a physique of knowledge by means of development reliable probabilistic models--and to automate the method up to attainable. during this booklet Pierre Baldi and Søren Brunak current the major desktop studying methods and observe them to the computational difficulties encountered within the research of organic information. The e-book is aimed either at biologists and biochemists who have to comprehend new data-driven algorithms and at people with a first-rate history in physics, arithmetic, statistics, or machine technological know-how who want to know extra approximately functions in molecular biology. This new moment variation includes elevated insurance of probabilistic graphical types and of the functions of neural networks, in addition to a brand new bankruptcy on microarrays and gene expression. the whole textual content has been broadly revised.

By Hirohisa Hirai, Hiroo Imai, Yasuhiro Go

ISBN-10: 4431540105

ISBN-13: 9784431540106

ISBN-10: 4431540113

ISBN-13: 9784431540113

In 2001, first studies of the human draft genome have been released. when you consider that then, genomes of many different organisms were sequenced, together with a number of primate species: the chimpanzee, rhesus macaque, gorilla, orangutan, gibbon, baboon, marmoset, tarsier, galago, lemur, and extra lately Neanderthals. In a brand new period of "post-genome biology", scientists now have the sizeable quantity of knowledge published by means of genome study to confront probably the most tough, primary questions in primatology and anthropology: What makes us human? This quantity contains a set of articles on numerous themes suitable to primate genomes, together with evolution, human origins, genome constitution, chromosome genomics, and bioinformatics. The ebook covers the state-of-the-art learn in molecular primatology and gives nice insights into the practical variety of primates. This important assortment will profit researchers and scholars, together with primatologists, anthropologists, molecular biologists, evolutionary biologists, and animal behaviorists.