By Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole
ISBN-10: 3662463059
ISBN-13: 9783662463055
This e-book presents an creation to the most recent gene mapping thoughts and their functions in biomedical examine and evolutionary biology. It specifically highlights the advances made in large-scale genomic sequencing. result of stories that illustrate how the recent techniques have more desirable our figuring out of the genetic foundation of advanced phenotypes together with multifactorial illnesses (e.g., heart problems, kind 2 diabetes, and obesity), anatomic features (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human mind constitution and nonhuman primate habit) are presented.
Topics lined contain linkage and organization equipment, gene expression, reproduction quantity version, next-generation sequencing, comparative genomics, inhabitants constitution, and a dialogue of the Human Genome undertaking. extra incorporated are discussions of using statistical genetic and genetic epidemiologic suggestions to decipher the genetic structure of standard and disease-related advanced phenotypes utilizing info from either people and non-human primates.
Read Online or Download Genome Mapping and Genomics in Human and Non-Human Primates PDF
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Extra resources for Genome Mapping and Genomics in Human and Non-Human Primates
Example text
HDAC inhibition was associated with global increases in histone acetylation, enhanced interactions of acetylated histones with the promoter regions of the P21 and BAX genes, and elevated expression of p21Cip1/Waf1 and BAX proteins. Importantly, sulphoraphane has been reported to reduce HDAC activity in humans (Myzak et al. 2006). Future research likely needs to relate HDAC changes in humans to a change in cancer-related processes. Furthermore, since acetylation is only one method to regulate histone homeostasis (Ross 2007), greater attention needs to be given to how 25 nutrition might influence the other types of histone modifications (Fenech et al.
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Genome Mapping and Genomics in Human and Non-Human Primates by Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole
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