By Luca Banfi, Andrea Basso, Renata Riva (auth.), Romano V. A. Orru, Eelco Ruijter (eds.)
ISBN-10: 364212674X
ISBN-13: 9783642126741
Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles via Classical Ugi and Passerini Reactions by means of Secondary modifications related to One or extra useful Groups.- V.A. Chebanov ∙ ok. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ ok. Khoury ∙ A. Dömling: Piperazine Scaffolds through Multicomponent three Reactions: The Piperazine house four in MCR Chemistry five Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G. Nenajdenko ∙ R.V.A. Orru: α-Acidic Isocyanides in Multicomponent Chemistry.- A. Cukalovic ∙ J.-C.M.R. Monbaliu ∙ C.V. Stevens: Microreactor expertise as an effective device for Multicomponent Reactions.- L.A. Wessjohann ∙ C.R.B. Rhoden ∙ D.G. Rivera ∙ O. Eichler Vercillo: Cyclic Peptidomimetics and Pseudopeptides from Multicomponent Reactions.- M. del Mar Sanchez Duque ∙ C. Allais ∙ N. Isambert ∙ T. Constantieux ∙ J. Rodriguez: ß-Diketo development Blocks for MCRs-Based Syntheses of Heterocycles
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Tetrahedron Lett 37:2943–2946 42. Spatz JH, Welsch SJ, Duhaut DE, Jager N, Boursier T, Fredrich M, Allmendinger L, Ross G, Kolb J, Burdack C et al (2009) Tetramic acid derivatives via Ugi-Dieckmann-reaction. Tetrahedron Lett 50:1705–1707 43. Seike H, Sorensen EJ (2008) A synthesis of the tricyclic core structure of FR901483 featuring an Ugi four-component coupling and a remarkably selective elimination reaction. Synlett 5:695–701 44. Marcaccini S, Pepino R, Cruz Pozo M (2001) A facile synthesis of 2, 5-diketopiperazines based on isocyanide chemistry.
Banfi L, Basso A, Guanti G, Lecinska P, Riva R, Rocca V (2007) Multicomponent synthesis of novel 2- and 3-substituted dihydrobenzo[1, 4]oxazepinones and tetrahydrobenzo[1, 4] diazepin-5-ones and their conformational analysis. Heterocycles 73:699–728 87. Tempest P, Pettus L, Gore V, Hulme C (2003) MCC/SNAr methodology. Part 2: Novel threestep solution phase access to libraries of benzodiazepines. Tetrahedron Lett 44:1947–1950 88. Spatz JH, Umkehrer M, Kalinski C, Ross G, Burdack C, Kolb J, Bach T (2007) Combinatorial synthesis of 4-oxo-4H-imidazo[1, 5-a]quinoxalines and 4-oxo-4H-pyrazolo[1, 5-a]quinoxalines.
72 3 Aminoazoles as 1,1-Binucleophiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 4 Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 Abbreviations 3-CR DMF DMSO MCR MW NMR p-TSA RT SAR US Three-component reaction Dimethylformamide Dimethylsulfoxide Multicomponent reaction Microwave Nuclear magnetic resonance para-Toluene sulfonic acid Reverse transcriptase Structure-activity relationship Ultrasonication 1 Introduction Binucleophiles of aminoazole-type are quite important reagents in modern heterocyclic chemistry, and their reactions with electrophiles are the most widespread and facile synthetic approach for obtaining diverse heterocyclic systems containing azole moiety [1–3].
Synthesis of Heterocycles via Multicomponent Reactions I by Luca Banfi, Andrea Basso, Renata Riva (auth.), Romano V. A. Orru, Eelco Ruijter (eds.)
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