By Hans-Joachim Bohm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
ISBN-10: 3527305211
ISBN-13: 9783527305216
The lock-and-key precept formulated through Emil Fischer as early because the finish of the nineteenth century has nonetheless no longer misplaced any of its importance for the existence sciences. the fundamental features of ligand-protein interplay should be summarized below the time period 'molecular popularity' and situation the specificity in addition to balance of ligand binding. Molecular attractiveness is therefore a primary subject within the improvement of energetic ingredients, considering the fact that balance and specificity make sure even if a substance can be utilized as a drug. these days, computer-aided prediction and clever molecular layout make a wide contribution to the consistent look for, e. g., more suitable enzyme inhibitors, and new recommendations comparable to that of pharmacophores are being built. An updated presentation of an perpetually younger subject, this publication is an crucial details resource for chemists, biochemists and pharmacologists facing the binding of ligands to proteins.
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Protein-ligand Interactions: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) by Hans-Joachim Bohm, Gisbert Schneider, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
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