Download PDF by Peter J. Quinn (Editor), Valerian E. Kagan (Editor): Phospholipid Metabolism in Apoptosis (Subcellular

By Peter J. Quinn (Editor), Valerian E. Kagan (Editor)

ISBN-10: 0306467828

ISBN-13: 9780306467820

ISBN-10: 0306479311

ISBN-13: 9780306479311

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Extra resources for Phospholipid Metabolism in Apoptosis (Subcellular Biochemistry, Volume 36) (Subcellular Biochemistry)

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Acad. Sci. USA 93: 1071-1076. , 2000, Cytochrome c release from mitochondria: all or nothing, Nature Cell Biology 2: E41-43. , 2001, Breaking the mitochondrial barrier, Molecular Cell Biology, 2: 63-67. , 1995, Translocation of apocytochrome c across the outer membrane of mitochondria, J. Biol. Chem. , 1999, An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol. 9: 323-328. , 1997, forms an ion channel in synthetic lipid membranes, Nature 385: 353-357. , 2001, A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c, EMBO J.

1997). A loss of is thought to be mediated by the opening of the mitochondrial permeability transition pore which is proposed to be involved in mitochondrial efflux of cytochrome c into the cytosol (Scarlett and Murphy, 1997). However, a recent report by Bossy-Wetzel et al. (1998) provided 28 Yoshihiro Shidoji et al. unequivocal evidence that the translocation of cytochrome c occurred prior to the dissipation of The underlying molecular mechanism for the translocation of cytochrome c has been virtually ignored at least that operating earlier than the opening of the mitochondrial permeability transition pore.

However, it decreased to in the presence of the activator cardiolipin. 8 nmol/min in the presence and absence of cardiolipin, respectively. 3 Effect of various lipids on PHGPx activity Cardiolipin consists of phosphatidylglycerol and phosphatidic acid. In order to see structural specificity of lipids as an activator, we examined the effect of various cardiolipin-related lipids in the place of cardiolipin on PHGPx activity. Figure 8 shows that cardiolipin from Eschericia coli was as potent an activator as cardiolipin from bovine heart.

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Phospholipid Metabolism in Apoptosis (Subcellular Biochemistry, Volume 36) (Subcellular Biochemistry) by Peter J. Quinn (Editor), Valerian E. Kagan (Editor)


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