By Christian Schudt, Gordon Dent, Klaus F. Rabe
ISBN-10: 0122107209
ISBN-13: 9780122107207
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), equivalent to theophylline, were used greatly considering 1958. within the decade of the '70s, numerous PDE isoenzymes have been outlined which ended in the advance of the second one new release of PDE inhibitors. at present numerous those new inhibitors are lower than try as power anti inflammatory medicines. in the past 5 years, molecular biology has published a superfamily of those phosphodiesterase isoenzymes. This booklet summarizes the current nation of data, in addition to giving a accomplished description of the compounds to be had. will probably be valuable for everybody who desires to decide on the main compatible PDE inhibitor for his or her study or who's facing such medicinal drugs in a scientific atmosphere. Key good points* makes use of genuine trying out and learn of recent PDE inhibitors* important for researchers and scholars alike
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Additional resources for Phosphodiesterase Inhibitors (Handbook of Immunopharmacology)
Example text
And Conti, M. (1992). Unique adenosine 3',5' cyclic monophosphate phosphodiesterase messenger ribonucleic acids in rat spermatogenic cells: evidence for differential gene expression during spermatogenesis. Biol. Reprod. 46, 1027-1033. Yan, C. A. (1994) Molecular cloning and cellular distribution of the 75 kDa calmodulin-dependent phosphodiesterase. FASEB J. 8, A81. K. A. (1994). Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J. Neurosci.
Munnich, A. and Kaplan, J. (1993). Physical and genetic localization of the y subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25). Genomics 17, 526-528. V. M. (1993). Characterization of a periplasmic 3': 5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibriofischeri. J. Bacteriol. 175, 4615-4624. , Fichtel, K. and Lubbert, H. (1994). Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett.
FASEB J. 8, A81. A. and Ferguson, K. (1996). Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5' cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271,796-806. C. L. (1991). Electron microscopic immunocytochemical evidence that the calmodulin-dependent cyclic nucleotide phosphodiesterase is localized predominantly at postsynaptic sites in the rat brain. Neuroscience 44, 491-500. D. A. (1991). High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.
Phosphodiesterase Inhibitors (Handbook of Immunopharmacology) by Christian Schudt, Gordon Dent, Klaus F. Rabe
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