By Yuriy Gusev
ISBN-10: 9814267015
ISBN-13: 9789814267014
This quantity comprises diversifications and important reports of the new state of the art microRNA examine reviews, starting from technological advances in microRNA detection and profiling, clinically orientated microRNA profiling in different human cancers, to a structures biology research of worldwide styles of microRNA rules of signaling and metabolic pathways. Interactions with transcription issue regulatory networks and mathematical modeling of miRNA law also are mentioned.
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Extra info for MicroRNA Profiling in Cancer: A Bioinformatics Perspective
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Cell 2006 Dec 15; 127(6):1193-207. 18. Weinstein JN, Pommier Y. Transcriptomic analysis of the NCI-60 cancer cell lines. C R Biol 2003 Oct; 326(10-11):909-20. 19. Ikediobi ON, Davies H, Bignell G, Edkins S, Stevens C, O'Meara S, et al. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther 2006 Nov; 5(11):260612. 46 R. Søkilde et al. 20. Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, et al. MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol Cancer Ther 2007 May 1; 6(5):1483-91.
Curry and R. Ach 61. Selbach, M; Schwanhausser, B; Thierfelder, N; Fang, Z; Khanin, R: Rajewsky, N: Widespread changes in protein synthesis induced by microRNAs. Nature 2008, 455: 58 – 63. 62. Baek, D; Villen, J; Shin, C; Camargo, FD; Gygi, SP; Bartel, DP: The impact of microRNAs on protein output. Nature 2008, 455: 64-71. 63. Creighton, CJ; Nagaraja, AK; Hanash, SM; Matzuk, MM; Gunaratne, PH: A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions.
When analyzing microRNA expression, it is, therefore, important that all variants are detected. The miRNA sequence annotated in miRBase will often be that of the predominant variant. 15 Wu et al. 16,17 Morin et al. 14 Techniques for detection of microRNAs often have different sensitivity towards such length variants because the assays, such as Q-RT-PCR, were microRNA Expression Analysis by LNA Enhanced Microarrays 29 Figure 5. The percentage of miRNAs detected when 50 amol of synthetic miRNA is spiked.
MicroRNA Profiling in Cancer: A Bioinformatics Perspective by Yuriy Gusev
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