By Gautam B. Singh
ISBN-10: 3319114034
ISBN-13: 9783319114033
This e-book deals accomplished assurance of all of the middle themes of bioinformatics, and comprises useful examples accomplished utilizing the MATLAB bioinformatics toolbox™. it really is basically meant as a textbook for engineering and machine technological know-how scholars attending complex undergraduate and graduate classes in bioinformatics and computational biology. The publication develops bioinformatics options from the floor up, beginning with an introductory bankruptcy on molecular biology and genetics. This bankruptcy will allow actual technology scholars to totally comprehend and relish the last word targets of utilising the rules of data know-how to demanding situations in organic facts administration, series research, and platforms biology. the 1st a part of the ebook additionally features a survey of latest organic databases, instruments that experience turn into crucial in today’s biotechnology learn. the second one a part of the e-book covers methodologies for retrieving organic info, together with basic algorithms for series comparability, scoring, and settling on evolutionary distance. the main target of the 3rd half is on modeling organic sequences and styles as Markov chains. It provides key ideas for studying and looking out for sequences of vital motifs and biomarkers. The final a part of the ebook, devoted to platforms biology, covers phylogenetic research and evolutionary tree computations, in addition to gene expression research with microarrays. briefly, the e-book deals the right hands-on reference advisor to the sphere of bioinformatics and computational biology.
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Additional info for Fundamentals of Bioinformatics and Computational Biology: Methods and Exercises in MATLAB (Modeling and Optimization in Science and Technologies, Volume 6)
Example text
The DNA replication results in the synthesis of the sister chromatid shown for each of the chromosome. All chromatid pairs are split into two diploid daughter cells. During mitosis prophase, the chromosomes condense and become visible under a light microscope with each chromosome consisting of parallel strands called the sister chromatids held together by the centromere. During prophase, the nuclear membrane disappears. During metaphase, the chromosomes contract and move towards the center of the cell and spindle fibers form and extend from the centromere to the centrioles located at the opposite poles of the cell.
1 Nucleotide Databases 45 Alternative Splicing The split gene structure of most eukaryote protein coding genes has a very important consequence; that by splicing the gene in different ways variant proteins can be produced. Thus, while there seems to be around twenty thousand (protein coding) genes in the Human Genome, there are many more different proteins; perhaps somewhere between one hundred thousand and one million - with the count depending as much on definitional issues as anything else. The two most basic forms of variation in splicing are shown in Fig.
TTT TTC TTA TTG F F L L Phe Phe Leu Leu i TCT TCC TCA TCG S S S S Ser Ser Ser Ser TAT TAC TAA TAG Y Y * * Tyr Tyr Ter Ter TGT TGC TGA TGG C C * W Cys Cys Ter Trp CTT CTC CTA CTG L L L L Leu Leu Leu Leu i CCT CCC CCA CCG P P P P Pro Pro Pro Pro CAT CAC CAA CAG H H Q Q His His Gln Gln CGT CGC CGA CGG R R R R Arg Arg Arg Arg ATT ATC ATA ATG I I I M Ile Ile Ile Met i ACT ACC ACA ACG T T T T Thr Thr Thr Thr AAT AAC AAA AAG N N K K Asn Asn Lys Lys AGT AGC AGA AGG S S R R Ser Ser Arg Arg GTT GTC GTA GTG V V V V Val Val Val Val GCT GCC GCA GCG A A A A Ala Ala Ala Ala GAT GAC GAA GAG D D E E Asp Asp Glu Glu GGT GGC GGA GGG G G G G Gly Gly Gly Gly Another shorthand notation of representing the standard genetic code where the IUPAC character encoding for the proteins is utilized is as follows: AAs Starts Base1 Base2 Base3 = = = = = FFLLSSSSYY**CC*WLLLLPPPPHHQQRRRRIIIMTTTTNNKKSSRRVVVVAAAADDEEGGGG ---M---------------M---------------M---------------------------TTTTTTTTTTTTTTTTCCCCCCCCCCCCCCCCAAAAAAAAAAAAAAAAGGGGGGGGGGGGGGGG TTTTCCCCAAAAGGGGTTTTCCCCAAAAGGGGTTTTCCCCAAAAGGGGTTTTCCCCAAAAGGGG TCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAGTCAG 1.
Fundamentals of Bioinformatics and Computational Biology: Methods and Exercises in MATLAB (Modeling and Optimization in Science and Technologies, Volume 6) by Gautam B. Singh
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