By Iman Tavassoly
ISBN-10: 331914961X
ISBN-13: 9783319149615
ISBN-10: 3319149628
ISBN-13: 9783319149622
This interdisciplinary thesis introduces a structures biology method of examine the mobile destiny determination mediated through autophagy. A mathematical version of interplay among Autophagy and Apoptosis in mammalian cells is proposed. during this dynamic version autophagy acts as a steady reaction to emphasize (Rheostat) that delays the initiation of bistable swap of apoptosis to offer the cells a chance to outlive. the writer indicates that his dynamical version is in keeping with latest quantitative measurements of time classes of autophagic responses to cisplatin therapy. to appreciate the functionality of this reaction in melanoma cells, he has supplied a platforms biology experimental framework to check quantitative and dynamical points of autophagy in unmarried melanoma cells utilizing live-cell imaging and quantitative fluorescence microscopy. This framework supplies new insights on functionality of autophagic reaction in melanoma cells.
Read or Download Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations PDF
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Extra info for Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations
Example text
Autoschizis: a novel cell death. Biochem. Pharmacol. 63(10), 1773–1783 (2002) 58. : Autophagy as a target for anticancer therapy. Nat. Rev. Clin. Oncol. 8(9), 528–539 (2011) 59. : Entosis: aneuploidy by invasion. Nat. Cell Biol. 13(3), 199 (2011) 60. : Snapshot: Selective autophagy. e2 (2013) 61. : mTOR regulation of autophagy. FEBS Lett. 584(7), 1287–1295 (2010) 62. : The beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18(4), 571–580 (2011) 63. : Shuttling of calcium between endoplasmic reticulum and mitochondria in the renal vasculature.
2, we combine all this information into a single influence diagram for the interaction of autophagy and apoptosis. This diagram will be used as the foundation for our mathematical model. 14 1 Introduction to Autophagy in Physiology and Pathophysiology Fig. 8 Interaction of BCL2, Beclin-1, and IP3R in ER References 15 References 1. : Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ. 14(3), 500–510 (2006) 2. : Cell cannibalism in ductal carcinoma of breast.
Treat. 112(3), 389–403 (2008) 109. : Er stress negatively regulates akt/tsc/mtor pathway to enhance autophagy. Autophagy 6(2), 239–247 (2010) 110. : Autophagy and metabolism. Sci. Signal. 330(6009), 1344 (2010) 111. : Inhibition of mtor induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of huntington disease. Nat. Genet. 36(6), 585–595 (2004) 20 1 Introduction to Autophagy in Physiology and Pathophysiology 112. : Coronaviruses hijack the lc3-i-positive edemosomes, er-derived vesicles exporting short-lived erad regulators, for replication.
Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations by Iman Tavassoly
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