Download PDF by Geoffrey Bourne (Eds.): The Structure and Function of Muscle. Volume II: Structure,

By Geoffrey Bourne (Eds.)

ISBN-10: 0121191028

ISBN-13: 9780121191023

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Additional info for The Structure and Function of Muscle. Volume II: Structure, Part 2

Example text

These experiments documented the block by electrophysiological evi­ dence (Csapo and Takeda, 1965), as will be described presently. However, the classic method used in cross-striated muscle for the Arpad I. Csapo 40 Pregnant ro Day 3 Day 2$ Parturient Day 31 Q) f-25^— 3fv*-i -¥- ■ψ^ kw^ Fig. 26. The progesterone block. Suction electrode recording technique, rabbit uteri at different days of pregnancy. C. pulses between a pair of electrodes 5 mm apart. The action potentials are recorded at 15, 30, and 45 mm distances from the stimulated region.

However, subsequent research showed that ovariectomy, carried out at different times in the same or in different species, had different conse­ quences. Progesterone withdrawal was not observed before parturition and replacement therapy was not effective in all species. Some observers, therefore, did not assign a key role to progesterone in the control of pregnancy and parturition. They preferred the view (Caldeyro-Barcia, 1964) that in different species basically different regulatory mechanisms control the same physiological functions, the maintenance of pregnancy, and the initiation of labor.

Parturient rat uterus, microelectrode technique. Note the slow waves, manifesting in cyclic depolar­ izations preceding the train discharges at pacemaker regions (A); the propagating train discharges not preceded by slow waves (B); and the local potentials manifesting in slight depolarizations unaccompanied by spikes (C). ) The conduction velocity in the same fiber bundle is a function of distance between the stimulating and recording electrodes. In the par­ turient uterus, values of 5-100 cm/sec were measured with microelectrodes at 5 mm and 50 μ distances, respectively (Kuriyama, 1961).

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The Structure and Function of Muscle. Volume II: Structure, Part 2 by Geoffrey Bourne (Eds.)


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