By Nancy Hogg, Carlos Cabañas, Ian Dransfield (auth.), Peter E. Lipsky M.D., Robert Rothlein Ph.D., Takashi Kei Kishimoto Ph.D., Ronald B. Faanes Ph.D., C. Wayne Smith M.D. (eds.)
ISBN-10: 1461392667
ISBN-13: 9781461392668
ISBN-10: 1461392683
ISBN-13: 9781461392682
Leukocyte adhesion molecules were the topic of extreme simple and preclinical study. effects from medical trials got sofar with antibodies directed in the direction of those floor proteins provide promise for the prevention of graft rejection and powerful therapy of acute and persistent inflammatory illness. This quantity offers a entire overview of up to date learn at the constitution, functionality and legislation of leukocyte adhesion molecules and their ligands, from the molecular to the medical point. The mixture of simple technological know-how and medical purposes offered in constitution, functionality and rules of Molecules concerned with Leukocyte Adhesion presents transparent proof of the organic value of cell-cell interactions and the various power scientific dividends afforded through figuring out the molecular foundation of phone adhesion. it's going to attract a vast diversity of readers in immunology and cellphone biology.
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Extra info for Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion: Proceedings of the Second International Conference on: “Structure and Function of Molecules Involved in Leukocyte Adhesion II”
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6. , P. van de Wiel-van Kemenade, P. W. G. Figdor. 1989. Enhancement of LFA-1 mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature 342:81l. 7. A. Springer. 1989. T cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619. 8. A. Cantrell. 1989. Kinases and phosphatases in T cell activation. Irnrnunol. Today 10:200. 24 Carl G. Figdor and Yvette van Kooyk 9. S. Geha, and T. Chatila. 1990. Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule-I-dependent cell adhesion.
1986. Contributions of the Mac-1 family to adherence-dependent granulocyte functions: structure-function assessments employing subunitspecific monoclonal antibodies. J. Immunol. 137: 15. 24. , C. Cabanas, J. Barrett, and N. Hogg. 1992. Interaction of leukocyte integrins with ligand is necessary but not sufficient for function. J. Cell Bio!. 116:1527. 25. H. A. F. Plow. 1990. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its a subunit.
161:446. 11. , D. Olive, A. J. Kozumbo, L. Moretta, and A. Moretta. 1987. Transmembrane signalling via the Til-dependent pathway of human T cell activation. Evidence for the involvement of 1,2-diacylglycerol and inositol phosphates. Eur. J. lmmunol. 17:55. 12. M. Theler, W. D. D. D. Lew. 1991. Multiple elevation of cytosolic free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family. J. Cell Bioi. 112:1249. 13. L. S. Edgington. 1990. Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18.
Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion: Proceedings of the Second International Conference on: “Structure and Function of Molecules Involved in Leukocyte Adhesion II” by Nancy Hogg, Carlos Cabañas, Ian Dransfield (auth.), Peter E. Lipsky M.D., Robert Rothlein Ph.D., Takashi Kei Kishimoto Ph.D., Ronald B. Faanes Ph.D., C. Wayne Smith M.D. (eds.)
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