By Sirkka Keränen, Jussi Jäntti
ISBN-10: 3540223029
ISBN-13: 9783540223023
This e-book offers with the molecular mechanisms of membrane trafficking, a relevant eukaryotic phone organic strategy. within the post-genomic period many crucial molecules inquisitive about intracellular membrane/protein shipping are rising. a major job now's to assemble the molecular networks that govern those methods. figuring out of regulatory approaches and taking part molecules tend to exhibit worldwide mobile regulatory circuits that couple membrane trafficking with different mobile features. Such phone organic gains are just beginning to emerge. This publication places exact emphasis on such mechanisms and techniques. The contents discusses the function of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. furthermore, the position of lipids in vesicle formation and membrane fusion, and a few really expert cellphone organic denovo membrane iteration tactics are mentioned.
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Read e-book online Regulatory Mechanisms of Intracellular Membrane Transport PDF
This ebook offers with the molecular mechanisms of membrane trafficking, a critical eukaryotic telephone organic technique. within the post-genomic period many crucial molecules interested by intracellular membrane/protein delivery are rising. a big job now could be to assemble the molecular networks that govern those approaches.
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Additional info for Regulatory Mechanisms of Intracellular Membrane Transport (Topics in Current Genetics)
Example text
2001), during the release of milk-fat globules from mammary gland epithelial cells (Deyrup-Olsen and Luchtel 1998), and during formation of filopodia, microvilli and other cell surface projections. Outward budding also concerns the assembly of enveloped viruses in infected cells (Pornillos et al. 2002) as well as the generation of the internal vesicles in multivesicular endosomes that, when released into the extracellular environment, are called exosomes (Katzmann et al. 2002). Exosomes contain MHC class II molecules and T cell co-stimulatory factors, and as such are potent modulators of the immune system (Thery et al.
Science 271:363-366 Friant S, Pecheur EI, Eugster A, Michel F, Lefkir Y, Nourrisson D, Letourneur F (2003) Ent3p Is a PtdIns(3,5)P2 effector required for protein sorting to the multivesicular body. Dev Cell 5:499-511. Gaidarov I, Keen JH (1999) Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. J Cell Biol 146:755-764 Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW, Keen JH, Benovic JL (1996) Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2adrenergic receptor.
Here, CCVs are generated that carry cargo from the secretory pathway to the endosomal and lysosomal systems. The molecular mechanisms that control clathrin-mediated budding and cargo selection at the TGN have not been as well defined as those at the plasma membrane. Interestingly, however, a series of recent studies have identified a consensus motif for interaction with the TGN clathrin adaptor AP-1. These studies have contributed to the identification of a series of proteins that appear to play regulatory roles in clathrin trafficking at the TGN, suggesting a molecular complexity for this event that may rival that seen at the plasma membrane.
Regulatory Mechanisms of Intracellular Membrane Transport (Topics in Current Genetics) by Sirkka Keränen, Jussi Jäntti
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