By Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski
ISBN-10: 0121533468
ISBN-13: 9780121533465
This publication is the 1st to target potassium ion channels and covers the hot extraordinary development made in study on those proteins. Many illnesses are attributable to the abnormalities of potassium ion channels. They contain diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal high blood pressure. Written via best scientists within the box, this quantity deals readers a accomplished replace of this box within the knowing of the genes, molecular constitution, functionality and illnesses of potassium ion channels.
Key Features
* the 1st entire quantity on potassium ion channels in all elements of genes, molecular constitution, functionality, and diseases
* thoroughly updated information
* Written by way of best scientists within the box
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Additional resources for Potassium Ion Channels Molecular Structure, Function, and Diseases
Sample text
E.. Fink. , Duprat, F.. Lazdunski. M.. Romey, G . and Barhaiiin. J. (1996). TWIK-1. a ubiquitous human weakly inward rectifiying K' channel with a novel structure. E M B O J. 15, 1004-101 I . 26 Lawrence Salkoff et af. , Reyes. , and Lazdunski, M. (1997). The structure, function and distribution of the mouse TWIK-1 K +channel. FEES Lett. 402,28-32. Li. , Jan. Y. , and Jan, L. Y. (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science 257, 1225-1230.
Sigg. , and Bezanilla, F. (1997). Total charge movement per channel: The relation between gating charge displacement and the voltage sensitivity of activation. J . Gen. Physiol. 109,27-39. , and Bezanilla, F. (1994). Gating current noise produced by elementary transitions in Shaker potassium channels. Science 264, 578-582. Sigworth, F. J. (1993). Voltage-gating of ion channels. Rev. Biophys. 27, 1-40. Starace, D. , and Bezanilla, F. (1997). Voltage-dependent proton transport by the voltage sensor of the Shaker K' channel.
1993). S4 mutations alter the single channel gating kinetics of Shaker K' channels. Neuron 11,343-352. Sigg. , and Bezanilla, F. (1997). Total charge movement per channel: The relation between gating charge displacement and the voltage sensitivity of activation. J . Gen. Physiol. 109,27-39. , and Bezanilla, F. (1994). Gating current noise produced by elementary transitions in Shaker potassium channels. Science 264, 578-582. Sigworth, F. J. (1993). Voltage-gating of ion channels. Rev. Biophys. 27, 1-40.
Potassium Ion Channels Molecular Structure, Function, and Diseases by Yoshihisa Kurachi, Lily Yeh Jan, Michel Lazdunski
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