By J. H. L. Playfair
ISBN-10: 0632054069
ISBN-13: 9780632054060
Immunology at a look is designed to be a concise, conveniently available advent and revision reduction for undergraduate clinical and technology scholars. Following the now usual, easy-to-use structure, every one subject is gifted as a double-page unfold with key proof observed via clear,informative line diagrams illustrating the basic points.The 7th version of this renowned immunology textbook has been thoroughly up to date to make sure that center wisdom approximately immunology is summarized within the 'at a look' format.Immunology At a look will proceed to attract all scholars of biomedical technology and medication who desire a speedy, but thorough take hold of of immunology. Condenses the topic into forty-one double-page spreads, every one corresponding approximately to a 50 minute lecture. provides a schematic diagram at the left web page and a concise rationalization at the correct exhibiting the mechanisms fascinated about immunological procedures. Has been thoroughly up-to-date with specific emphasis on contemporary knowing of the genetic foundation of immune responses Immunology at a look will proceed to entice all scholars of biomedical technology and drugs who desire a fast, but thorough, clutch of immunology.
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Extra resources for Immunology at a glance
Example text
The antibody repertoire of an animal, stored in its V genes and expanded further by mutation (see Fig. 15),is expressed as the number of different shapes towards which a complementary specific antibody molecule can be made, and runs into millions. What happens when antigen and antibody combine depends on the circumstances. Sometimes antibody alone is enough to neutralize the antigen, as in the case of those toxins or micro-organisms which need to 44 Adaptive immunity attach to cell surface receptors in order to gain entry; antibody can often block this.
Peptides MHC Class I1 molecules can bind peptides up to 20 amino acids long -longer than Class I MHC since the MHC Class I1 peptide binding groove allows peptides to extend out of each end. g. persistent bacteria such as TB), but also includes many self-peptides, many of which are derived from MHC molecules themselves. The binding of peptides to MHC is facilitated and regulated by two other Class 11-like molecules HLA-DM and HLA-DO which are also found within the processing endosome. e. cytokine secretion; see Fig.
See Fig. 7) can perform this function, part of which consists of releasing Interleukin- 1 (IL- 1) (see below) but which in the case of T lymphocytes also requires the presence of Class I1 MHC molecules on the APC. Except with small peptides that can associate directly with MHC, antigens have to be processed first (see Fig. 17, right-hand side, for an enlarged version of this stage). FDC The follicular dendritic cell, specialized for presenting antigen to B lymphocytes in the B cell follicles. Antigen on the surface of FDC is largely intact, maintaining its native conformation, and is often held in the form of antibody/antigen complexes which can persist for weeks or months.
Immunology at a glance by J. H. L. Playfair
by Christopher
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