By E. Ghigo, M. Boghen, Felipe F. Casanueva, C. Dieguez
ISBN-10: 0444829334
ISBN-13: 9780444829337
Development hormone secretagogues (GHS) administered by myself or together with development hormone freeing hexapeptides, are potent probes for the analysis of GH deficiency in either young ones and adults. present learn has built and confirmed various GHS compounds which are lively by way of the oral path, and feature more suitable efficiency and bioavailability, giving upward thrust to intriguing healing probabilities. there has been an enthusiastic reaction from specialists during this region to the assumption of distilling the massive volume of accessible facts into one multi-authored quantity. every one contributor has complex the sphere of data, and has the following emphasised the sensible facets in their paintings, reviewing the topic within the gentle in their personal event. consequently, the subject of the booklet is a pragmatic one. the quantity offers with all elements of GHS which are suitable to the sector, from the chemical constitution to the several analogues, to the cloning and expression of the GHS-receptor and the position of those compounds within the physiological keep watch over of GH secretion. additionally mentioned are the latest advances when it comes to the prospective function of those compounds within the diagnostic healing settings in several medical events, both in young ones, adults or the aged. The publication meets the requirement of overlaying so much, if now not the entire advances within the box. it is going to let scientists and clinicians to maintain abreast of the speedily evolving wisdom of the latest years, and also will turn out worthwhile as a assessment for all drawn to this subject.
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Extra resources for Growth Hormone Secretagogues: Basic Findings and Clinical Implications
Example text
This lack of biological knowledge has impacted the choice of assays for testing for GH-releasing activity and testing for the specificity of pituitary hormone release. There is also very limited published data on GHRP efficacy in animals, beyond data on GH release, and because of this there is also a similar paucity of data on the optimal or most efficacious pattern of GHRP exposure. This lack of efficacy data in animals, and appropriate models for testing molecules and delivery patterns, and therefore a lack of information on optimal routes and patterns of administration, has perhaps contributed to the development of GHRPs in humans being much slower than one would have originally predicted.
1980) Oxidation of Tryptophan to Oxindolylalanine by Dimethylsulfoxide-Hydrochloric Acid. Int. J. Peptide Protein Res. 15,285-297. 10. , et al. (1997) GHRP Receptors in Pituitary, Central Nervous System and Peripheral Human Tissues. Abs. 186, J. Endocrinol. Invest. 20 (suppl. to No. 4), 52. 11. K, et al. (1994) Disposition of Growth HormoneReleasing Peptide (SK&F 110679) in rat and dog following intravenous or subcutaneous administration. Drug Metab. Dispos. 22,90-98. Growth Hormone Secretagogues Edited by E.
In: Growth Hormone Secretagogues. B. F. Walker (eds). Springer, New York, pp. 9-25. 2. , Camanni F. (1997) Growth Hormone-Releasing Peptides. European J. Endocrin. 136,445-460. 3. T. (1997). Growth Hormone Secretagogues. Ann. reports in Med. Chem. Vol 32,221-230. 4. D. et al. (1997) Peptidomimetic Regulation of Growth Hormone Secretion. Endocrine Reviews 18,621-645. 5. Deghenghi, R. (1996) Examorelin. Drugs of the Future 21 (4), 366-368. 6. , Torsello, A. et al. (1994) GH-Releasing Activity of Hexarelin, a new Growth Hormone-Releasing Peptide, in infant and adult rats.
Growth Hormone Secretagogues: Basic Findings and Clinical Implications by E. Ghigo, M. Boghen, Felipe F. Casanueva, C. Dieguez
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