By Fuki Hisama, Sherman M. Weissman, George M. Martin
This article examines the connection among DNA harm and service, mobile senescence, genomic instability, and getting older. The authors supply in-depth discussions of varied kinds of DNA harm, the DNA fix community, and mobile responses to genetic harm to evaluate their effect at the modulation of getting older tactics and age-related ailments, together with melanoma improvement. Chromosomal Instability and getting older describes cloning genes for human chromosomal instability issues, the causal components and effects of chromosomal harm, the telomere speculation of getting older, and age-dependant mitochondrial genetic instability. It comprises greater than 2200 references to facilitate extra learn, making it an informative and well timed consultant.
Read or Download Chromosomal instability and aging : basic science and clinical implications PDF
Similar basic science books
Designed as an relief to scholars in Genetics counseling sessions and pros drawn to honing their talents, Facilitating the Genetic Counseling procedure will consultant the reader during the why's and how's of helping consumers with those advanced matters. The authors' collective years of either instructing scholars and counseling consumers is mirrored within the transparent, functional procedure of this handbook.
What elements permit members to beat opposed childhoods and flow directly to profitable lives in maturity? Drawing on facts accrued from of Britain's richest examine assets for the research of human improvement, the 1958 nationwide baby improvement examine and the 1970 British Cohort research, Schoon investigates the phenomenon of 'resilience' - the power to regulate certainly to opposed stipulations.
A brand new, case-oriented and functional advisor to at least one of the middle options in respiration drugs and important care. Concise, functional reference designed to be used within the serious care settingCase-oriented content material is organised in accordance with generally encountered medical scenariosFlow charts and algorithms delineate acceptable remedy protocols
Biostatistics and Microbiology allows the reader to entry and practice statistical tools that ordinarily frustrate and intimidate the uninitiated. facts, like chemistry, microbiology, woodworking, or stitching, calls for that the person positioned a while into studying the techniques and strategies. This booklet offers a step by step demeanour that removes the best challenge to the learner, that is making use of the numerous techniques that include a statistical strategy.
- Veterinary Vaccines and Diagnostics
- Desk Reference for Hematology
- Molecular biology problem solver : a laboratory guide
- Molecular Biology Techniques: An Intensive Laboratory Course
Additional resources for Chromosomal instability and aging : basic science and clinical implications
All Rights Reserved. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. DP Barlow, R Stoger, BG Herrmann, K Saito, N Schweifer. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature 349:84–87, 1991. MS Bartolomei, S Zemel, SM Tilghman. Parental imprinting of the mouse H19 gene. Nature 351:153–155, 1991. TM DeChiara, EJ Robertson, A Efstratiadis. Parental imprinting of the mouse insulinlike growth factor II gene. Cell 64:849–859, 1991.
Proc Natl Acad Sci USA 90:7915–7922, 1993. M Corral-Debrinski, T Horton, MT Lott, JM Shoffner, MF Beal, DC Wallace. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 2:324–329, 1992. EE Jazin, L Cavelier, I Eriksson, L Oreland, U Gyllensten. Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA. Proc Natl Acad Sci USA 93:12382–12387, 1996. Y Michikawa, F Mazzucchelli, N Bresolin, G Scarlato, G Attardi.
All Rights Reserved. Nagai, YI Nabeshima. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45–51, 1997. 60. T Utsugi, T Ohno, Y Ohyama, T Uchiyama, Y Saito, Y Matsumura, H Aizawa, H Itoh, M Kurabayashi, S Kawazu, S Tomono, Y Oka, T Suga, M Kuro-o, Y Nabeshima, R Nagai. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49:1118–1123, 2000. 61. SD Tyner, S Venkatachalam, J Choi, S Jones, N Ghebranious, H Igelmann, X Lu, G Soron, B Cooper, C Brayton, S Hee Park, T Thompson, G Karsenty, A Bradley, LA Donehower.
Chromosomal instability and aging : basic science and clinical implications by Fuki Hisama, Sherman M. Weissman, George M. Martin