By Icon Health Publications
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Additional resources for Celecoxib - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Following surgical resection, a small but significant minority of patients with early stage rectal cancer experience lethal recurrences of their tumors. For this subset of patients, adjuvant therapy has, to date, shown no significant benefit. Increased expression of cyclooxygenase-2 (COX-2) occurs in ~80 percent of colorectal cancers, and several lines of evidence suggest that this increased COX-2 expression may promote tumor progression through increased tumor cell survival, increased invasiveness and increased tumor-associated angiogenesis.
Measures of drug effect (EGFR, c-fos, apoptosis) and biomarkers of lung cancer risk will be measured in bronchial epithelium before and after taking drug for 12 weeks. Potential efficacy of EGFR and/or COX-2 inhibition (using ZD1839 and Celecoxib, respectively) will then be assessed in a Phase II, placebo-controlled, clinical trial assessing effect on bronchial epithelial genetic loss and other surrogate biomarkers of lung cancer risk. ; Professor of Medicine and Pharmacology; University of Arizona P O Box 3308 Tucson, Az 857223308 Timing: Fiscal Year 2002 Summary: Colorectal cancer continues as the third leading cause of cancer death in both males and females in the United States.
We will evaluate these subjects clinically using structured, standardized methods of assessment and diagnosis. 05) to detect a 30% reduction in incidence among the treated groups. In this application we proposed the first 42-54 months of treatment with an interim analysis of efficacy after the last-enrolled subject has completed 30 months. At that point, the study will have 80% power to detect a 50% reduction in AD incidence with either agent, in which case the trial can be stopped. The trial should also be stropped if there is no apparent benefit of treatment, or if safety issues mandate.
Celecoxib - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications