By National Academies Press
ISBN-10: 0309100925
ISBN-13: 9780309100922
ISBN-10: 0309656524
ISBN-13: 9780309656528
Read or Download Toxicity Testing for Assessment of Environmental Agents: Interim Report PDF
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Extra resources for Toxicity Testing for Assessment of Environmental Agents: Interim Report
Sample text
The committee supports the general approach used by ILSI-HESI to tailor testing to meet risk-assessment needs. Specifically, ILSI-HESI proposed using exposure considerations (such as the difference between doses that produce effects in animals and expected human exposure to pesticides) to provide a conceptual framework for guiding the selection and extent of testing. That approach, however, may not be useful for chemicals for which the degree and circumstances of human exposure are difficult to predict.
Population data will be available only on chemicals that have been in production for some time, perhaps several decades. Thus, differences in data availability on new versus existing chemicals Copyright © National Academy of Sciences. All rights reserved. html 5 Summary should be considered in developing the role of human data in any toxicity-testing strategy. Human data come primarily from epidemiologic studies, which investigate the relationship between exposure to a substance and potential health effects in a human population.
Pesticides EPA, • Establish contaminant concentrations at which “no known or anticipated adverse effects on the health of persons occur and which allows an adequate margin of safety”; may consider feasibility EPA, water Safe Drinking Water Copyright © National Academy of Sciences. All rights reserved. S. html 18 Copyright © National Academy of Sciences. All rights reserved. • Approval of new drug applications, considering risks and benefits FDA, drug 21 USC § 355(d) Consumer Product • “Eliminate or reduce an unreasonable risk of • Mandatory safety standards • Bans Safety Act/15 USC §§ injury associated with” consumer products; • Recalls 2057, 2058 (2003) considers costs and benefits CPSC b Amends the Federal Food, Drug, and Cosmetic Act.
Toxicity Testing for Assessment of Environmental Agents: Interim Report by National Academies Press
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