By Adriano G. Rossi, Deborah A. Sawatzky
ISBN-10: 3764375051
ISBN-13: 9783764375058
ISBN-10: 376437506X
ISBN-13: 9783764375065
Read Online or Download The Resolution of Inflammation (Progress in Inflammation Research) (Progress in Inflammation Research) PDF
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Additional info for The Resolution of Inflammation (Progress in Inflammation Research) (Progress in Inflammation Research)
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The Resolution of Inflammation, edited by Adriano G. Rossi and Deborah A. Sawatzky © 2008 Birkhäuser Verlag Basel/Switzerland 39 Andrew Devitt and Christopher D. Gregory The innate immune system The innate immune system is a powerful (if often under-rated) system that constitutes an important early defence against pathogens. g. g. g. g. chemokines). In this chapter we seek to review the published role of innate immune components in the context of apoptotic cell clearance with a focus upon the resolution of inflammation.
Pattern recognition The concept of self/non-self recognition is central to immunology – how and why do we respond to some antigens and not others? Janeway [2] proposed that the innate immune system discriminated ‘non-self’ (‘infectious non-self’) from ‘self’ (‘noninfectious self’) at the point of recognition: the former being foreign and exposed patterns that are evolutionarily conserved (so-called pathogen-associated molecular patterns or PAMPs) and such PAMPs were proposed to be recognised by specialised receptors known as pattern recognition receptors (PRRs).
J Biol Chem 274: 37329–37334 De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA (2002) Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. Blood 99: 3432–3438 Kobayashi S, Yamashita K, Takeoka T, Ohtsuki T, Suzuki Y, Takahashi R, Yamamoto K, Kaufmann SH, Uchiyama T, Sasada M, Takahashi A (2002) Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.
The Resolution of Inflammation (Progress in Inflammation Research) (Progress in Inflammation Research) by Adriano G. Rossi, Deborah A. Sawatzky
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