Get Molecular mechanisms that orchestrate the assembly of PDF

By Cornelis Murre

ISBN-10: 0128032960

ISBN-13: 9780128032961

ISBN-10: 0128033304

ISBN-13: 9780128033302

Molecular Mechanisms That Orchestrate the meeting of Antigen Receptor Loci, the most recent quantity within the Advances in Immunology sequence specializes in the iteration of a good immune reaction to invading pathogens

As B and T lymphocytes are characterised by way of the expression of antigen receptors that in particular realize determinants expressed on pathogens, this quantity discusses how antigen receptors are synthesized in B and T lymphocytes.

  • Focuses at the iteration of a good immune reaction to invading pathogens
  • Contains contributions from best authorities
  • Informs and updates on all of the most recent advancements within the box of immunology

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Extra info for Molecular mechanisms that orchestrate the assembly of antigen receptor loci

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RAG represents a widespread threat to the lymphocyte genome. Cell. (in press). , & Alt, F. W. (2014). Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immun. Res, 2(9), 857–866. CIR-14-0090. Thompson, C. B. (1995). New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity, 3(5), 531–539. Tsai, A. , Raghavan, S. , Hsieh, C. , & Lieber, M. R. (2008). Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.

00835-07. Dudley, D. , Sadofsky, M. , et al. (2003). Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. The Journal of Experimental Medicine, 198(9), 1439–1450. 20030627. Eastman, Q. , Villey, I. , & Schatz, D. G. (1999). Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking. Molecular and Cellular Biology, 19(5), 3788–3797. , Schwickert, T. , & Busslinger, M. (2013). Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

AT-hook motifs identified in a wide variety of DNAbinding proteins. Nucleic Acids Research, 26(19), 4413–4421. Arbuckle, J. , Fauss, L. , Ptaszek, L. , & Rodgers, K. K. (2001). Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination. The Journal of Biological Chemistry, 276(40), 37093–37101. M105988200. 28 Grace Teng and David G. Schatz Arbuckle, J. , Rahman, N. , & Rodgers, K. K. (2011). Elucidating the domain architecture and functions of non-core RAG1: The capacity of a noncore zinc-binding domain to function in nuclear import and nucleic acid binding.

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Molecular mechanisms that orchestrate the assembly of antigen receptor loci by Cornelis Murre


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