By Stephan Herzig (eds.)
ISBN-10: 3319298046
ISBN-13: 9783319298047
ISBN-10: 3319298062
ISBN-13: 9783319298061
The HEP factor on Metabolic regulate presents a state-of the paintings evaluate over either classical techniques and rising components in metabolism and linked issues. during this context, metabolic keep watch over is highlighted at quite a few degrees of complexity starting from transcriptional mechanisms in metabolic pathway regulate over metabolic communique routes in body structure and pathophysiology to present remedy modalities and strategies in metabolic issues, together with sort 2 diabetes and weight problems. devoted chapters by means of top specialists of their fields offer a concise review over very important parts in metabolic study at a molecular point, together with the function of the vital frightened method in metabolism, irritation and metabolism, pancreatic hormone signaling, brown adipose tissue, and healing concepts.
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Additional info for Metabolic Control
Sample text
In addition to its effects on insulin secretion, β-cell growth and proliferation, cAMP may also enhance differentiation. GLP-1 appears to increase the expression of pancreatic duodenal homeobox – 1 (PDX-1) (Perfetti et al. 2000), a transcription factor central to the differentiation of pancreatic endocrine, exocrine, and ductal cell populations from endoderm during fetal development (Zhou et al. 2002; Offield et al. 1996). PDX-1 is also necessary for maturation of β-cells and allows selective differentiation of pancreatic endocrine progenitors to form insulin-producing β-cells while suppressing formation of glucagon-producing α-cells (McKinnon and Docherty 2001; Ber et al.
Nat Methods 6(4):283–289. doi:10. 1313 Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-Andre V, Sigova AA, Hoke HA, Young RA (2013) Super-enhancers in the control of cell identity and disease. Cell 155(4):934–947. 1016/j. 053 Hong SH, Ahmadian M, Yu RT, Atkins AR, Downes M, Evans RM (2014) Nuclear receptors and metabolism: from feast to famine. Diabetologia 57(5):860–867. 1007/s00125-0143209-9 Howald C, Tanzer A, Chrast J, Kokocinski F, Derrien T, Walters N, Gonzalez JM, Frankish A, Aken BL, Hourlier T, Vogel JH, White S, Searle S, Harrow J, Hubbard TJ, Guigo R, Reymond A (2012) Combining RT-PCR-seq and RNA-seq to catalog all genic elements encoded in the human genome.
PKA maintains temporal Role of the cAMP Pathway in Glucose and Lipid Metabolism 35 autoregulation of the cAMP signal while promoting lipolysis by allowing PDE3B fine-tuning of the cAMP signal to a concentration range that is ideal to sustain activity, whereas AKT blocks lipolysis by dissociating it from lipolytic signals at least in part by activating discrete pools of PDE3B. Significantly, PDE3B mutant mice show hepatic lipid accumulation and insulin resistance, suggesting that the increase in lipolysis is not accompanied by an increase in fatty acid oxidation and may reflect the redundancy between PDE family members or the diminished importance of PDE3B in the regulation of fatty acid oxidation in non-adipose tissues such as the liver.
Metabolic Control by Stephan Herzig (eds.)
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