By Ernst Rainer Weissenbacher (auth.)
ISBN-10: 3642149057
ISBN-13: 9783642149054
ISBN-10: 3642149065
ISBN-13: 9783642149061
This booklet systematically experiences and discusses fresh experiences and articles at the immunology of woman genital tract tissue. The scope is extensive, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of standard and irregular being pregnant, and immunological infertility. all through, tables and illustrations are judiciously used to facilitate knowing. Immunology of the feminine Genital Tract will function a useful resource of updated info for all with an curiosity during this subject.
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Extra info for Immunology of the Female Genital Tract
Example text
Some studies showed a predominance of IgG in cervical secretions but a higher proportion of specific IgA antibodies in secretions from women colonized with group B streptococci in their cervix or rectum. Additionally, IgG is also predominant in vaginal fluid while IgA can be detected in mucus mostly from the endocervix. However, there is a predominance of IgG in cervical mucus with a peak before the time of ovulation together with smaller preovulatory peaks of IgA and IgM. Interestingly, IgG appeared to be the predominant Ig in CVS, but the ratios of IgG to IgA varied from 2:1 to 10:1.
When compared with women on birth control pills, the mean peak of IgA detected was about one-third less in normal ovulating women. This supports the general agreement that reproductive hormones enhance immunity. 6 Antigen Presentation As mentioned previously, the role of APCs throughout the body as well as at mucosal surfaces is central to the generation of immune protection. An effective immune response requires that exogenous antigen is internalized, processed, and returned to the cell surface of APCs in association with MHC class II for recognition by CD4+ T cells.
More recent studies demonstrated that stromal antigen presentation is regulated by cytokine production by ECs. In response to estrogen, uterine ECs produce TGF-β which suppresses underlying APCs in the stroma. It can be concluded that uterine ECs as well as APCs in the uterine stroma and vagina are capable of presenting antigen which initiates an immune response in the female reproductive tract. Moreover, sex hormones play a principal role in regulating antigen presentation in the genital tract.
Immunology of the Female Genital Tract by Ernst Rainer Weissenbacher (auth.)
by George
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