By Christine A. Orengo, Alex Bateman, Vladimir Uversky
New insights into the evolution and nature of proteins
Exploring a number of precise methods, this ebook describes the equipment for evaluating protein sequences and protein buildings for you to establish homologous relationships and classify proteins and protein domain names into evolutionary households. Readers will detect the typical good points in addition to the foremost philosophical variations underlying the foremost protein category platforms, together with Pfam, Panther, SCOP, and CATH. furthermore, they're going to realize how those structures can be utilized to appreciate the evolution of protein households in addition to comprehend and are expecting the measure to which structural and sensible info are shared among kinfolk in a protein relations.
Edited and authored through prime foreign specialists, Protein households offers new insights into protein households which are vital to clinical study in addition to protein households that aid us comprehend organic structures and key organic methods equivalent to phone signaling and the immune reaction. The publication is split into 3 sections:
- Section I: options Underlying Protein kinfolk Classification studies the main concepts for choosing homologous proteins and classifying them into families.
- Section II: In-Depth studies of Protein households focuses on a few attention-grabbing great protein households for which we have now great quantities of series, structural and useful information, making it attainable to track the emergence of functionally diversified relatives.
- Section III: assessment of Protein households in vital organic Systems examines protein households linked to a selected organic topic, akin to the cytoskeleton.
All chapters are largely illustrated, together with depictions of evolutionary relationships. References on the finish of every bankruptcy advisor readers to unique study papers and reports within the box.
Covering protein relations type platforms along exact descriptions of decide on protein households, this publication deals biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new perception into the evolution and nature of proteins.Content:
Chapter 1 computerized Sequence‐Based techniques for picking out area households (pages 1–24): Liisa Holm and Andreas Heger
Chapter 2 series class of Protein households: Pfam and different assets (pages 25–36): Alex Bateman
Chapter three Classifying Proteins into area constitution households (pages 37–68): Alison Cuff, Alexey Murzin and Christine Orengo
Chapter four Structural Annotations of Genomes with Superfamily and G3D (pages 69–97): Julian Gough, Corin Yeats and Christine Orengo
Chapter five Phylogenomic Databases and Orthology Prediction (pages 99–124): Kimmen Sjölander
Chapter 6 The Nucleophilic assault Six‐Bladed β‐Propeller (N6P) Superfamily (pages 125–158): Michael A. Hicks, Alan E. Barber and Patricia C. Babbitt
Chapter 7 practical variety of the HUP area Superfamily (pages 159–189): Benoit H. Dessailly and Christine Orengo
Chapter eight The NAD Binding area and the Short‐Chain Dehydrogenase/Reductase (SDR) Superfamily (pages 191–206): Nicholas Furnham, Gemma L. Holliday and Janet M. Thornton
Chapter nine The Globin family members (pages 207–235): Arthur M. Lesk and Juliette T.J. Lecomte
Chapter 10 sensible version and Plasticity in Cytoskeletal Protein domain names: classes from the Erythrocyte version (pages 237–284): Anthony J. Baines
Chapter eleven strange Species Distribution and Horizontal move of Peptidases (pages 285–314): Neil D. Rawlings
Chapter 12 Deducing delivery Protein Evolution in keeping with series, constitution, and serve as (pages 315–339): Steven T. Wakabayashi, Maksim A. Shlykov, Ujjwal Kumar, Vamsee S. Reddy, Ankur Malhotra, Erik L. Clarke, Jonathan S. Chen, Rostislav Castillo, Russell de l. a. Mare, Eric I. solar and Milton H. Saier
Chapter 14 households of Sequence‐Specific DNA‐Binding domain names in Transcription elements around the Tree of existence (pages 383–420): Varodom Charoensawan and Sarah Teichmann
Chapter 15 Evolution of Eukaryotic Chromatin Proteins and Transcription elements (pages 421–502): L. Aravind, Vivek Anantharaman, Saraswathi Abhiman and Lakshminarayan M. Iyer
Chapter thirteen CRISPR‐Cas platforms and Cas Protein households (pages 341–381): Kira S. Makarova, Daniel H. Haft and Eugene V. Koonin