By Mulchand S. Patel, Frank Jordan
ISBN-10: 0824740629
ISBN-13: 9780824740627
Thiamine: Catalytic Mechanisms in general and ailment States brings jointly the latest advancements in thiamine diphosphate (TDP)-requiring enzyme study and information the mechanisms of catalysis and structure-function relationships, in addition to pathophysiological features of a spectrum of illnesses linked to TDP-requiring enzymes. supplying new insights into neurogenerative ailments, this quantity affiliates defects within the functionality of TDP-dependent enzymes with a variety of metabolic problems and illness states and gives novel features of thiamine enzymes in chiral synthesis in addition to new views at the mobile position of thiamine triphosphate and thiamine triphosphates.
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Additional resources for Thiamine: Catalytic Mechanisms in Normal and Disease States (Oxidative Stress and Disease)
Example text
V Job, GL Marcone, MS Pilone, L Pollegioni. Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein. J Biol Chem 277:6985–6993, 2002. V Job, G Molla, MS Pilone, L Pollegioni. Overexpression of a recombinant wild-type and His-tagged Bacillus subtilis glycine oxidase in Escherichia coli. Eur J Biochem 269:1456–1463, 2002. Y Nishiya, T Imanaka. Purification and characterization of a novel glycine oxidase from Bacillus subtilis. FEBS Lett 438:263–266, 1998. Mechanisms and Structures of Thiamine Biosynthesis 9.
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Structure and Function of TPK 33 Figure 2 Ethanol effect on mTPK activity. 4) at 22oC, respectively. No alcohol inhibition on the recombinant enzyme was observed. Mouse TPK was found to be expressed mainly in liver and kidney when the cDNA was untilized as a probe for Northern blots (9). However, human TPK, which has an 89% sequence identity to mouse TPK, was expressed in a wide variety of tissues, with very low amounts, if any, in brain (23). Considering the importance of TPP for metabolism in brain tissues and the previous reports of TPK activity in brain extracts, the finding that ethanol does not inhibit recombinant mTPK suggests that there may be another isoform of TPK specifically expressed in the brain, which can be inhibited by ethanol.
Thiamine: Catalytic Mechanisms in Normal and Disease States (Oxidative Stress and Disease) by Mulchand S. Patel, Frank Jordan
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