By Alain Dabdoub, Bernd Fritzsch, Arthur N. Popper, Richard R. Fay
ISBN-10: 1493930303
ISBN-13: 9781493930302
ISBN-10: 1493930311
ISBN-13: 9781493930319
This quantity info the fundamental position of the spiral ganglion neurons. the amount elucidates and characterizes their improvement, their setting, their electrophysiological features, their connectivity to their pursuits within the internal ear and the mind, and discusses the possibility of their regeneration. A finished assessment concerning the spiral ganglion neurons is necessary for researchers not just within the internal ear box but additionally in improvement, neuroscience, biophysics in addition to neural networks researchers. The chapters are authored by means of prime researchers within the field.
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Extra info for The Primary Auditory Neurons of the Mammalian Cochlea
Example text
2009) suggests this could reflect a selective loss of vestibular neurons. , 2008). As in other regions of the nervous system, the final number of neurons in the SG reflects a balance of proliferation and apoptosis. , 2012). , 2001). , 2013). Thus, early neuroblasts require signaling through the Akt pathway for their survival. Apoptosis also affects subsequent stages of SGN development, after the neurons have exited the cell cycle and differentiated. Classic in vitro assays originally showed that SGN survival depends on target-derived cues present both in the sensory epithelia and in the hindbrain (Zhou & Van De Water, 1987).
However, loss of the PNSD from Shh mutant mice does not appear to be a direct effect on otic vesicle patterning, as otic-specific ablation of the Shh receptor Smoothened did not reproduce this effect. , 2005). , 2006; Brown & Epstein, 2011). , 2006). , 2003, 2010; Hammond & Whitfield, 2011). The basis of these apparent differences among species is unclear but could reflect unique features of different types of vertebrate ears. 2 21 Intrinsic Patterning Mechanisms Although signals extrinsic to the ear likely initiate the events that place the PNSD in the anterior otic cup, transcriptional networks and local cell–cell interactions play an important role in reinforcing these decisions and ensuring the neurosensory competence of cells within this domain.
These studies also uncovered a dose dependence that may influence the ultimate outcome of each FGF signal. How FGFs affect the delamination and expansion of neuroblasts in mouse is not known. V. , 2003). , 2009) suggests this could reflect a selective loss of vestibular neurons. , 2008). As in other regions of the nervous system, the final number of neurons in the SG reflects a balance of proliferation and apoptosis. , 2012). , 2001). , 2013). Thus, early neuroblasts require signaling through the Akt pathway for their survival.
The Primary Auditory Neurons of the Mammalian Cochlea by Alain Dabdoub, Bernd Fritzsch, Arthur N. Popper, Richard R. Fay
by Ronald
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