Download e-book for kindle: The HLA FactsBook by Steven G. E. Marsh

By Steven G. E. Marsh

ISBN-10: 0125450257

ISBN-13: 9780125450256

Any immunologists and virologists attracted to determining antigenic epitopes for vaccine improvement want this booklet to lead them.

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Sample text

These cells have specialized mechanisms for engulfing, killing and degrading extracellular pathogens. For example, macrophages phagocytose bacteria and degrade them in endosomes and lysosomes. Peptides derived from these processes tend to be bound by class II molecules because they bind peptides within endosomal vesicles.

HLA-E alleles E*0101 E*0102 E*01031 E*01032 E*0104 Table 9. HLA-G alleles G*01011 G*01012 G*01013 G*01014 G*01015 G*01016 G*01017 G*01018 G*0102 G*0103 G*01041 G*01042 G*01043 G*0105N codons. Alleles of this type are collectively called null alleles. They are considered to be subtypes of their parent alleles and accordingly given a unique number at the third and fourth digits. In addition they are given the suffix 'N' to indicate null or non-expression. For example, two rare null alleles called HLAA*2409N and HLA-A*2411N are related to the common HLA-A*2402 allele by single nucleotide changes^.

In cases where the serology is uncertain or has not been examined, a number not carried by any serological antigen is assigned. In other instances, where the serological description poorly reflects the structure of the allotype, the Table 6. HLA-B alleles B*07021 B*07022 B*07023 B*0703 B*0704 B*0705 B*0706 B*0707 B*0708 B*0709 B*0710 B*0711 B*0712 B*0713 B*0801 B*0802 B*0803 B*0804 B*0805 B*0806 B*1301 B*1302 B*1303 B*1304 B*1401 B*1402 B*1403 B*1404 B*1405 B*1535 B*1536 B*1537 B*1538 B*1539 B*1540 B*1542 B*1543 B*1544 BM545 B*1546 B*1547 B*1548 B*1549 B*1801 Bn802 B*1803 B*1804 B*1805 B*1806 B*1807 B*2701 B*2702 B*2703 B*2704 B*27052 B*27053 B*2706 B*2707 B*3701 B*3702 B*3801 B*38021 B*38022 B*3803 B*39011 B*39013 B*39021 B*39022 B*3903 B*3904 B*3905 B*39061 B*39062 B*3907 B*3908 B*3909 B*3910 B*3911 B*3912 B*3913 B*3914 B*3915 B*3916 BMOOll BM0012 B*4002 B*4003 B*4702 BM703 B*4801 B*4802 BM803 B*4804 B*4805 B*4901 B*5001 B*5002 B*51011 B*51012 B*51021 B*51022 B*5103 B*5104 B*5105 B*5106 B*5107 B*5108 B*5109 B*5110 B*5111N B*5112 B*5113 B*5114 B*5115 B*5116 B*52011 Continued leles: Workshops and Nomenclature Table 6.

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The HLA FactsBook by Steven G. E. Marsh


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