By Rajesh K. Gaur, John J. Rossi
ISBN-10: 0849391695
ISBN-13: 9780849391699
New Findings Revolutionize options of Gene functionality Endogenous small RNAs were present in a variety of organisms, together with people, mice, flies, worms, fungi, and micro organism. moreover, it’s been proven that microRNAs appearing as mobile rheostats be ready to modulate gene expression. In larger eukaryotes, microRNAs may perhaps keep an eye on up to 50 percentage of gene expression. legislation of Gene Expression through Small RNAs brings jointly the pioneering paintings of researchers who talk about their paintings concerning a wide selection of small RNA regulatory pathways in organisms starting from micro organism to people. as well as exploring the biogenesis and processing of those regulatory RNAs, additionally they give some thought to the sensible significance of those pathways in host organisms. supporting present and destiny researchers, this specified groundbreaking paintings — offers a collection of state of the art assets for the examine of microRNA ontology and serve as features a expertise consultant for these looking to assay microRNA expression Explores the mechanisms through which microRNAs control gene expression in animal cells, together with the legislation of gene expression by way of RNA-mediated transcriptional gene silencing Discusses a quick and inexpensive technique for reversing genetic impacts in mammals appears at breakthroughs within the use of microRNA-based treatment for HIV and melanoma This quantity captures the essence of the breadth and pleasure surrounding the newly chanced on regulatory roles of small RNAs. The strong new technique within the learn of gene functionality defined during this textual content is resulting in a few extraordinary findings that experience the capability to revolutionize our realizing of genetic functionality and the remedy of ailments in a different way thought of intractable.
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Extra info for Regulation of gene expression by small RNAs
Example text
9 CONCLUSIONS In the end, identifying an miRNA’s targets is more interesting than identifying the miRNA itself. Thus, one can argue that once one has identified a RISC-dependent target of a small RNA that maps to a genomic hairpin, the RNA should be annotated as an miRNA. We would, however, caution that, even though miRNAs and siRNAs are the only distinct RNAs currently known to be incorporated into RISC, the latter may also associate with other small RNAs that have their own distinct processing pathways.
15. , and Jin, Y. , Computational identification of novel family members of microRNA genes in Arabidopsis thaliana and Oryza sativa, Acta Biochim Biophys Sin (Shanghai) 37 (2), 75–87, 2005. 16. Lim, L. , Lau, N. , Weinstein, E. , Rhoades, M. , Burge, C. , and Bartel, D. , The microRNAs of Caenorhabditis elegans, Genes Dev 17 (8), 991–1008, 2003. 17. , Lim, L. , Bartel, D. , and Burge, C. , Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification, RNA 10 (9), 1309–1322, 2004.
One study of the ability of a mir-30 precursor to migrate from the nucleus to the cytoplasm shows that Exportin-5 likely recognizes most other parts of the pre-miRNA [73]. Proper Microprocessor processing seems to be important, as 5b overhangs are inhibitory for transport, suggesting that the twonucleotide 3b overhang of pre-miRNAs is pivotal for cytoplasmic export. 1 Structural features implicated in Microprocessor processing of pri-miRNAs. The figure shows the hsa-mir-23a hairpin structure as predicted by RNAfold [77].
Regulation of gene expression by small RNAs by Rajesh K. Gaur, John J. Rossi
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