By F. A. Kincl, J. R. Pasqualini
ISBN-10: 0080197086
ISBN-13: 9780080197081
Written via the world's top researchers in steroid biochemistry this quantity describes the ways that hormonal focus is regulated while pregnant. it's a entire account of ways biosynthesis, metabolism and inter-compartmental shipping are regarding the focus of every hormone present in placental, fetal and maternal cubicles. there's additionally an introductory bankruptcy on hormonal mechanism of motion
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Extra info for Production, Concentration and Metabolism During Pregnancy. Production, Concentration & Metabolism During Pregnancy
Sample text
Mitosis are frequently seen, the epithelium becomes higher and more columnar and the glands become well developed and tortuous. The stroma cells of the superficial layer may become separated by edema fluid. During the secretoary (luteal) phase, gland cells accumulate glycogen, the glands become dilated and filled with secretion and there is a major increase in the growth and tortuosity of arterioles. If implantation does not take place, breaks in the surface occur, pieces of glands and stroma are lifted off and desquamation takes place.
Quoted from Loraine and Bell (1968). 200 h ^ Estrone-3-Glu (a) Λ 150 CN / 1 iooh 50 \ h I 150 LH peak S V I I I I I J I I I Α\Λ/ν- ^ I I I ι ι Estradiol-3-Glu (b) J I 1 I I I I L J I Λ ι Λ l Estradiol-17/3-Glu 50 25 14 -,--f—f—R'L 12 10 8 6 4 ι 2 ι 0 ι 2 ι 4 ι 6 ι J ι I I 8 10 12 14 Days of cycle Fig. 26. Urinary Excretion of Estrone-3- (a), Estradiol-3(b) and Estradiol-17β-Glucuronides (c) During the Human Menstrual Cycle. Quoted from Baker et al. (1979). The values are expressed in nmol/24 h.
T h i s a s s u m p t i o n is b a s e d o n t h e v a r i a t i o n of e s t r a d i o l / e s t r i o l p l a s m a r a t i o s d u r i n g t h e cycle, b u t m o r e d e t a i l e d studies a r e n e e d e d to p r o v i d e a definitive a n s w e r . , 1979, 1980). W r i g h t et al. (1979) c o n f i r m e d t h e d a t a of B a k e r et al. (1979) a n d r e p o r t e d t h e following v a l u e s of t o t a l g l u c u r o n i d e s : 2 - 9 / i g / 2 4 h in t h e m i d d l e of t h e follicular p h a s e , 1 3 - 2 5 in m i d - c y c l e a n d 5 - 2 3 jug/24 h in t h e m i d d l e of t h e l u t e a l p h a s e .
Production, Concentration and Metabolism During Pregnancy. Production, Concentration & Metabolism During Pregnancy by F. A. Kincl, J. R. Pasqualini
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