By Ángel García-Alonso, Yotis Senis
ISBN-10: 0470463376
ISBN-13: 9780470463376
The aim of the ebook is to introduce platelets, and their practical position in thrombotic and heart problems, justifying the relevance of platelet proteomics learn. concentration then shifts to the hot advancements on mass spectrometry (MS)-based proteomics. This bankruptcy exhibits power functions for platelet proteomics now not but carried out. It contains examples of post-translational variations (PTMs) research in platelets.
The moment a part of the booklet makes a speciality of the most study performed thus far on platelet proteomics. This contains common proteome mapping by way of non-gel dependent separation tools (MudPit), research of the final platelet proteome and signaling cascades by way of gel-based separation equipment (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). eventually, the final part hyperlinks the platelet transcriptome and alertness to disease. This part is very suitable and comprises chapters on proteomics, transcriptomics, sensible genomics, structures biology, and their purposes to platelet-related diseases.
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Additional info for Platelet Proteomics: Principles, Analysis, and Applications
Sample text
Gibbins JM, Platelet adhesion signaling and the regulation of thrombus formation, J. Cell. Sci . 117(Pt. 16):3415–3425 (2004). 18. Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP, Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets, J. Biol. Chem. 271(30):18095–18099 (1996). 18 THE IMPACT OF PROTEOMIC ANALYSIS 19. Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP, Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain, FEBS Lett.
24 THE IMPACT OF PROTEOMIC ANALYSIS 121. Ruiz FA, Lea CR, Oldfield E, Docampo R, Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes, J. Biol. Chem. 279(43):44250–44257 (2004). 122. Maynard DM, Heijnen HF, Horne MK, White JG, Gahl WA, Proteomic analysis of platelet alpha-granules using mass spectrometry, J. Thromb. Haemost. 5(9):1945–1955 (2007). 123. , Organellar proteomics of human platelet dense granules reveals that 14–3-3zeta is a granule protein related to atherosclerosis, J.
1 Gel-Based Separation In 1975, two-dimensional gel electrophoresis (2DGE; also abbreviated 2-DE) was independently invented by O’Farrell [1] and Klose [2]. This technique is based on the subsequent separation of proteins referring to two independent physicochemical properties. In the first dimension, proteins are separated according to their net charge in an isoelectric focusing (IEF) step, whereas in the second dimension the proteins are separated according to their molecular weight (MW) in a common sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE).
Platelet Proteomics: Principles, Analysis, and Applications by Ángel García-Alonso, Yotis Senis
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