By Yasuhiko Tomino
ISBN-10: 4431555870
ISBN-13: 9784431555872
ISBN-10: 4431555889
ISBN-13: 9784431555889
This booklet discusses the most recent findings at the pathogenesis and remedy of IgA nephropathy. It quite makes a speciality of lately well-known initiation and development elements and the various therapy suggestions in several areas, comparable to Asia, Europe, and the USA. greater than forty years have handed considering that Dr. Jean Berger first defined basic IgA nephropathy (“Nephropathy with mesangial IgA-IgG deposits”) as a brand new disorder entity.
Immunohistopathologically, IgA nephropathy is characterised via the granular deposition of IgA (IgA1) and C3 within the glomerular mesangial parts with mesangial mobilephone proliferation and the growth of mesangial matrices. it really is transparent that IgA nephropathy is without doubt one of the commonest kinds of persistent glomerulonephritis on the earth. This disorder could lead to end-stage kidney ailment, with its huge, immense monetary influence on healthcare in every single place. Efforts via many investigators all over the world have steadily clarified numerous features of the pathogenesis and therapy of IgA nephropathy. although, there are numerous arguable concepts for the therapy of sufferers with IgA nephropathy during the international, as there are a number of boundaries for therapy in every one kingdom. This quantity presents nephrologists in all places with an outline and comparability of either worldwide and nearby findings in uncomplicated and medical fields in IgA nephropathy. It covers genetic edition, aberrant IgA1 construction, and class etiology, directions, and remedy targets, with all chapters written by means of best overseas researchers.
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Additional info for Pathogenesis and Treatment in IgA Nephropathy: An International Comparison
Sample text
Coppo R, Amore A, Chiesa M, Lombardo F, Cirina P, Andrulli S, et al. Serological and genetic factors in early recurrence of IgA nephropathy after renal transplantation. Clin Transplant. 2007;21:728–37. 125. Li GS, Zhang H, Lv JC, Shen Y, Wang HY. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int. 2007;71:448–53. 126. Li GS, Zhu L, Zhang H, Lv JC, Ding JX, Zhao MH, et al. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy.
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Pathogenesis and Treatment in IgA Nephropathy: An International Comparison by Yasuhiko Tomino
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