Get Neurogenic Inflammation in Health and Disease PDF

By Gabor Jancso

ISBN-10: 0444532293

ISBN-13: 9780444532299

Morphological and useful experiences printed a posh process of fundamental sensory neurons which parallels the autonomic apprehensive process not just in its quantity, yet most likely additionally in its importance. Neuropeptides published from activated nociceptive afferent nerves play a pivotal position in inflammatory reactions and ache, considerably modulate cardiac, vascular, breathing, gastrointestinal and immune features and effect the protecting, restorative and trophic services of somatic and visceral tissues. a number of chapters of the booklet take care of the healing strength of a brand new type of putative ache relieving brokers appearing via TRPV1, the capsaicin/vanilloid receptor, a selected ion channel which transmits ache. *Neurogenic irritation in historic perspective*Cardiac safety through nociceptive afferents*Molecular mechanisms of nociception*Sensory mechanisms in migraine pathophysiology*Vagal signalling of visceral inflammation*Neurogenic mechanisms in arthritis*Therapeutic implications of vanilloid-type compounds

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Additional info for Neurogenic Inflammation in Health and Disease

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Jancso´ N. Neurogenic inflammatory responses. Acta Physiol Acad Sci Hung 1964;(Suppl 23):3–4. 15. Dale HH. Pharmacology and nerve-endings. Proc R Soc Med 1935;28:319–332. 16. Jancso´ G, Kiraly E, Jancso´-Ga´bor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 1977;270:741–743. 17. Jancso´ G. Degenerative changes induced by capsaicin and related vanilloids in primary sensory neurones. J Physiol (Lond) 2000;526:9S–10S. 18. Jancso´ G, Kira´ly E.

Sa´ntha P, Pierau FK, Jancso´ G. Galanin mediated inhibitory nervous modulation of cutaneous vascular reactions. Acta Physiol Hung 1999;86:279–285. 128. Jancso´ G, Sa´ntha P, Horva´th V, Pierau F-K. Inhibitory neurogenic modulation of histamine-induced cutaneous plasma extravasation in the pigeon. Regul Pept 2000;95:75–80. ´ , Pozsgai G, Brain SD, Helyes ZS, Szolcsa´nyi J, Ghosh M et al. Mustard oil 129. Ba´nvo¨lgyi A induces a transient receptor potential vaniloid 1 receptor-independent neurogenic inflammation and a non-neurogenic cellular inflammatory component in mice.

FASEB J 2003;17:1871–1885. 118. Sta¨nder S, Steinhoff M, Schmelz M, Weisshaar E, Metze D, Luger T. Neurophysiology of puritus: cutaneous elicitation of itch. Arch Dermatol 2003;39:1463–1470. 119. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS et al. Proteinaseactivated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003;23:6176–6180. ´ , Blumberg PM, Nilsson S, Ho¨kfelt T, Lundberg JM. Visualization by [3H]resi120. Sza´lla´si A niferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man.

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Neurogenic Inflammation in Health and Disease by Gabor Jancso


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