By D. B. Boyd, J. D. Snoddy (auth.), David Shugar, Wojciech Rode, Edward Borowski (eds.)
ISBN-10: 3662027402
ISBN-13: 9783662027400
ISBN-10: 3662027429
ISBN-13: 9783662027424
While serendipity and random screening proceed to fulfil an important position within the look for new medicines, present impressive advances in molecular biology and genetics are dictating to a profound quantity the methods hired of their improvement. expanding recognition is being dedicated to investigations of the mechanisms of motion of present medicinal drugs, and the resources of undesired uncomfortable side effects, on the molecular point. the data so derived is now largely utilized, by means of extensive inter disciplinary techniques, either theoretical and experimental, to advancements in latest medications, and the rational layout of latest ones. The foregoing comprised the subject material of the third Inter nationwide Symposium on "Molecular facets of Chemotherapy", lower than the auspices of the overseas Society of Chemotherapy, and arranged by way of the Committee on Drug examine, Polish Academy of Sciences, and the dep. of Biotechnology and Biochemistry, Technical college of Gdansk. This quantity contains the texts of the evaluation lectures offered by means of invited members on up to date achievements, and destiny views, in molecular mechanisms of inhibition of mobile capabilities and metabolism, with emphasis at the layout and mechanisms of motion of chemotherapeutic brokers for therapy of bacterial, neoplastic, viral and parasitic illnesses. From the Contents, it is going to be obvious that the diversity of disciplines represented was once a huge one, together with theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary periods have been supple mented via numerous poster sessions.
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Extra resources for Molecular Aspects of Chemotherapy: Proceedings of the Third International Symposium on Molecular Aspects of Chemotherapy Gdansk, Poland June 19–21, 1991
Example text
A two-dimensional 1H-NMR study of the (+ )-CC-1065 I2-mer duplex adduct shows that there is a discontinuity between the 9T_16A and lOA_15T base pairs, Sequence Recognition of DNA by (+ )-CC-1065 47 which is characterized by a highly propeller twisted lOA_15T [17]. 07 ppm, indicative of a considerably weakened hydrogen-bonding interaction. This discontinuity may well be responsible for the bending of DNA induced by (+ )-CC-1065, which appears to be at least superficially similar in magnitude, direction, and in structural origin to that associated with intrinsic A-tract bending [13].
20: 163-174,1985 10. Mabilia M, Pearlstein RA and Hopfinger AJ, Computer graphics in molecular shape analysis. 157-182, 1986. 11. Hopfinger AJ, Conformational Properties ofMacromolecules, Academic Press, New York, 1973. 12. Matthews DA, Bolin TJ, Burridge JM, Filman DJ, Volz KW, Kaufman BT, Beddell CR, Champness IN, Stemmers DK and Kraut J, X-ray crystallography of L. Casei dihydrofolate reductase. J. Bioi. Chem. 281: 260-267,1985. 13. , Lake Forest, IL 60045,1990. 14. Burkert U and Allinger NL, Molecular Mechanics, American Chemical Society, Washington DC, 1982.
Vo does not contain information regarding the intramolecular stability of each conformation of the pair of compounds from which they are derived. Loss in conformational stability in order to realize particular measures in Vo was taken into account by defining the shape commonality index, Ie: where S (u, U, w) is wVo, and M; is the difference in conformational energy between the global minimum and the conformation used to compute Vo for analog x = u and/or U [19]. The parameter w is a weighting factor between shape similarity and loss in intramolecular conformational stability.
Molecular Aspects of Chemotherapy: Proceedings of the Third International Symposium on Molecular Aspects of Chemotherapy Gdansk, Poland June 19–21, 1991 by D. B. Boyd, J. D. Snoddy (auth.), David Shugar, Wojciech Rode, Edward Borowski (eds.)
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