By Arthur M. Lesk
ISBN-10: 0199564353
ISBN-13: 9780199564354
Our genome is the blueprint to our lifestyles: it encodes all of the details we have to boost from a unmarried phone right into a highly advanced practical organism. yet how will we determine the genes that make up our genome? How will we be sure their functionality? and the way do assorted genes shape the regulatory networks that direct the approaches of life?
Introduction to Genomics is an interesting perception into what could be printed from the examine of genomes: how organisms range or fit; how diverse organisms developed; how the genome is developed and the way it operates; and what our figuring out of genome constitution and serve as capability when it comes to our overall healthiness and health.
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Additional resources for Introduction to Genomics
Sample text
3 Genome sequencing projects. gov/genome A viroid is a small single-stranded RNA which can replicate autonomously, but does not encode protein, nor is encapsulated within a coat. b There are many reasons for sequencing non-human genomes. The most important ones are that they reveal the processes of evolution, and that they help us to understand the functions of different regions of the human genome. Other genomes are essential to illuminate ours. An important principle is that if evolution conserves something, it is essential.
Analysis of patients’ genes and proteins permits selection of drugs and dosages optimal for individual patients, a field called pharmacogenomics. Physicians can thereby avoid experimenting with different ther- 23 apies, a procedure that is dangerous in terms of side effects – sometimes even fatal – and in any case is wasteful and expensive. Treatment of patients for adverse reactions to prescribed drugs consumes billions of dollars in health care costs. Conversely, being able to predict individual patients’ responses can make it possible to rescue drugs that are safe and effective in a minority of patients, but which have been rejected before or during clinical trials because of inefficacy or severe side effects in the majority of patients.
Assembly: the inference of the complete sequence of a region from the data on individual fragments from the region, by piecing together overlaps. Contig: a partial assembly of data from overlapping fragments into a contiguous region of sequence. De novo sequencing: determination of a full-genome sequence without using a known reference sequence from an individual of the species to avoid the assembly step. Resequencing: determination of the sequence of an individual of a species for which a reference genome sequence is known.
Introduction to Genomics by Arthur M. Lesk
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