New PDF release: Heterocyclic Antitumor Antibiotics

By Toni Brown, Herman Holt Jr., Moses Lee (auth.), Moses Lee (eds.)

ISBN-10: 3540309829

ISBN-13: 9783540309826

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"Heterocyclic antitumor antibiotics characterize a large classification of average items which are of common curiosity … . therefore, a well-written, up to date account of development within the research of such compounds is anticipated to be good obtained. … this monograph definitely has adequate medical price to benefit inclusion in so much educational libraries and in business laboratories occupied with antibacterial and anticancer agent discovery. person researchers, however, may first desire to weigh the level to which this far-ranging number of studies bargains sufficiently with issues of particular curiosity to their examine teams ahead of buying a private copy." (Gary I. Dmitrienko, magazine of the yank Chemical Society, Vol. 129, 2007)

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Scheme 20 demonstrates this procedure as a feasible means of producing the Merck anti-inflammatory drug Vioxx, 85. 3 Dihydrofuan Compounds Scheme 21 shows the synthesis of a dihydrofuran derivative 86. Synthesis of this compound was described by Nam et al. [68] utilizing a furanone compound 87 synthesized by Kim et al. [61] via a similar synthetic approach as described in Scheme 17. The lactone was reduced using lithium aluminum hydride to give the diol 88 and intramolecular etherification using the Mitsunobu reaction afforded the dihydrofuran 86 in moderate yield (47%).

Xu J, Ma L, Jiao P (2004) Chem Commun 1616 83. Pinney KG, Bounds AB, Dingeman KM, Mocharla VP, Pettit GR, Bai R, Hamel E (1999) Bioorg Med Chem Lett 9:1081 84. Buron F, Plé N, Turck A, Queguiner G (2005) J Org Chem 70:2616 85. Szczepankiewicz BG, Liu G, Jae HS, Tasker AS, Gunawardana IW, von Geldern TW, Gwaltney II SL, Ruth Wu-Wong J, Gehrke L, Chiou WJ, Credo RB, Adler JD, Nukkala MA, Zielinski NA, Jarvis K, Mollison KW, Frost DJ, Bauch JL, Hui YH, Claiborne AK, Li Q, Rosenberg SH (2001) J Med Chem 44:4416 86.

Also described the synthesis of the fused indoles [73]. The o-iodotrifluoroacetanilide 110 was coupled to aryl alkyne 111 under Sonogashira conditions followed by subsequent reaction with aryl iodide, 107 with gaseous carbon dioxide produced the fused indole 158. Lewis acid dealkylation with aluminum trichloride produced the deprotected alcohol 159. 40 T. Brown et al. , published the synthesis of botryllazine derivatives containing a pyrazine core [84]. Scheme 42 describes the synthesis of these compounds.

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Heterocyclic Antitumor Antibiotics by Toni Brown, Herman Holt Jr., Moses Lee (auth.), Moses Lee (eds.)


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