Group B Coxsackieviruses by Steven Tracy, M. Steven Oberste, Kristen M. Drescher PDF

By Steven Tracy, M. Steven Oberste, Kristen M. Drescher

ISBN-10: 3540755454

ISBN-13: 9783540755456

Our wisdom of the crowd B coxsackieviruses has advanced dramatically some time past 60 years. probably the most fresh advances comprise the identity of the coxsackievirus-adenovirus receptor, the dissection of genetic components associated with virulence/attenuation, exam of the effect of recombination in virus evolution and variety, and research of the position of viral proteins in regulating host telephone macromolecule synthesis and trafficking. the 1st variation of this paintings, released in 1997, defined the molecular biology of coxsackie B viruses, in addition to scientific, epidemiological, and immunological points of team B coxsackievirus ailment. a lot has been entire long ago ten years, together with selection of the crystal constitution of a virus-receptor complicated, major advances in knowing the molecular info of virus-host interplay in the cellphone, and deeper insights into the systemic results of virus an infection and the host reaction. This moment variation summarizes the present kingdom of information in crew B coxsackievirus genomics and replication, receptor constitution and serve as, host phone interactions, the host immune reaction and immunopathology, viral virulence and pathogenesis, and the position of this crucial team of viruses in acute and protracted ailment in humans.

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2005) scheduled to initiate phase 2 trials in 2007. Lethal mutagenesis is amply supported by theoretical studies when the latter are based on realistic assumptions. Remarkably, the nucleoside analog ribavirin has been shown to act as mutagen for poliovirus (Crotty et al. 2000, 2001; Graci and Cameron 2006) and several other RNA viruses. Ribavirin tri-phosphate can act as a substrate analog, and the monophosphate is incorporated into viral RNA, resulting in increases in mutation frequency and decreases in viral infectivity, in some cases accompanied by viral Coxsackieviruses and Quasispecies Theory: Evolution of Enteroviruses 23 extinction.

1992). 20 7 E. Domingo et al. Enterovirus Evolution in the Course of Persistent Infections Several enteroviruses cause pathology in association with persistence in specific cells and tissues of infected organisms. Persistence both in vivo and in model systems in cell culture is the result of a complex interplay between viral and host influences. Early studies in cell culture documented evidence of coevolution of persistently infected cells and their resident virus. In a coxsackie A9-HeLa carrier cell system, cells with increased resistance to the virus, and viruses with increased virulence for HeLa cells were selected (Takemoto and Habel 1959).

J Biotechnol 44:119-128 26 E. Domingo et al. Agol VI, Belov GA, Cherkasova EA, Gavrilin GV, Kolesnikova MS, Romanova LI, Tolskaya EA (2001) Some problems of molecular biology of poliovirus infection relevant to pathogenesis, viral spread and evolution. Dev Biol (Basel) 105:43-50 Anderson JP, Daifuku R, Loeb LA (2004) Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol 58:183-205 Arita M, Zhu SL, Yoshida H, Yoneyama T, Miyamura T, Shimizu H (2005) A Sabin 3-derived poliovirus recombinant contained a sequence homologous with indigenous human enterovirus species C in the viral polymerase coding region.

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Group B Coxsackieviruses by Steven Tracy, M. Steven Oberste, Kristen M. Drescher


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