From genes to genomes : concepts and applications of DNA by Jeremy W. Dale, Malcolm von Schantz, Nicholas Plant PDF

By Jeremy W. Dale, Malcolm von Schantz, Nicholas Plant

ISBN-10: 0470017333

ISBN-13: 9780470017333

ISBN-10: 0470017341

ISBN-13: 9780470017340

''...an first-class book...achieves all of its ambitions with sort, readability and completeness...You can see the facility and probabilities of molecular genetics as you read...'' -Human Genetics ''This quantity hits an exceptional stability between clarity, insurance, and detail.'' -Biochemistry and Molecular Biology schooling fast advances in a suite of thoughts often called gene know-how, genetic engineering, recombinant DNA expertise and gene cloning have driven molecular biology to the vanguard of the organic sciences. This re-creation of a concise, well-written textbook introduces key innovations and ideas excited about cloning genes and in learning their expression and version. The booklet opens with a quick assessment of the fundamental innovations of molecular biology, sooner than relocating directly to describe the main molecular tools and the way they healthy jointly. This levels from the cloning and research of person genes to the sequencing of complete genomes, and the research of genome-wide details. eventually, the booklet strikes directly to think of a few of the functions of those thoughts, in biotechnology, medication and agriculture, in addition to in learn that's inflicting the present explosion of information around the organic sciences. From Genes to Genomes: strategies and functions of DNA expertise, moment version comprises complete two-colour layout all through and an accompanying web site. particular alterations for the hot version include:* Strengthening of gene to genome subject* Updating and reinforcing of fabric on proteomics, gene remedy and stem cells* extra eukaryotic/mammalian examples and not more specialize in micro organism This textbook is must-have for all undergraduates learning intermediate molecular genetics in the organic and biomedical sciences. it's also of curiosity for researchers and all these wanting to replace their wisdom of this swiftly relocating box

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11). indd 39 9/5/2007 10:57:44 AM 40 CH3 HOW TO CLONE A GENE plasmid. ) Relaxed and supercoiled plasmids show different relative mobilities, and both are different from linear molecules. Unless plasmids are linearized before electrophoresis by digestion with restriction enzymes, a special supercoiled molecular weight marker has to be used. Most RNA molecules you will encounter are single-stranded, and in some cases (such as in DNA sequencing) we will come across single-stranded DNA as well. These need special consideration.

Indd 21 9/5/2007 10:57:00 AM 22 CH2 BASIC MOLECULAR BIOLOGY number of separate polypeptides. This can occur by the ribosomes reaching the stop codon at the end of one polypeptide-coding sequence, terminating translation and releasing the product before re-initiating (without dissociation from the mRNA). Alternatively, the ribosomes may attach independently to internal ribosome binding sites within the mRNA sequence. e. expression of each gene in the operon goes up (or down) together in response to changing conditions.

These four bases (AATT) are the same on all fragments generated with this enzyme, and these ends are complementary to one another. They will thus tend to form base pairs, and so help to stick the fragments together. They are therefore referred to as cohesive or sticky ends. Note that the base pairing formed with a sequence of four bases is very weak and would not be stable, so we need to use DNA ligase to finally join the fragments together with a covalent bond to form a recombinant molecule (see below).

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From genes to genomes : concepts and applications of DNA technology by Jeremy W. Dale, Malcolm von Schantz, Nicholas Plant


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