By Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council, Commission on Life Sciences
ISBN-10: 0309073162
ISBN-13: 9780309073165
Record of the Subcommittee on Reproductive and Developmental Toxicology of suggested methods that may be used to judge chemical compounds and actual brokers for his or her strength to reason reproductive and developmental toxicology and the way those methods can be utilized by way of the army. Softcover.
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Additional info for Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity
Sample text
Identify areas of needed research. For the purposes of this study, the primary focus is on avoiding occupational exposures to agents that potentially cause reproductive and developmental toxicity. Therefore, this report recommends a process that focuses on evaluating exposures to adult male and female military and civilian personnel and on predicting the effects of those exposures on those adults and their children. It does not specifically address direct exposures to children of military and civilian personnel, including children living on military bases.
Please use the print version of this publication as the authoritative version for attribution. html INTRODUCTION 11 1 Introduction isorders of human reproduction and development affect a substantial number of individuals of all ages and have long-standing implications for the public in terms of both quality of life issues and economic costs. Although reproductive disorders typically affect younger individuals, they also have implications for long-term health status. For example, men with impaired fecundity (the biological capacity for reproduction) could be at increased risk for testicular cancer (Moller and Skakkebaek 1999) and women with early onset of menopause could be at increased risk of osteoporosis (Bagur and Mautalen 1992; Ohta et al.
Other factors that should be considered include statistical power, analytical approaches, data presentation, and consistency with other results. Qualities and Limitations of Reproductive and Developmental Toxicity Studies Developmental toxicity studies typically assess whether structural abnormalities are associated with administration of an agent to a pregnant female during major organogenesis in the developing embryo. General reproductive effects can be assessed through analysis of various types of mating studies.
Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity by Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council, Commission on Life Sciences
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