Download e-book for iPad: Essentials of Apoptosis. A Guide for Basic and Clinical by Xiao-Ming Yin, Zheng Dong

By Xiao-Ming Yin, Zheng Dong

ISBN-10: 1588291464

ISBN-13: 9781588291462

Uncomplicated and medical investigators systematically assemble a entire yet concise precis of crucial, up to date information regarding apoptosis. The authors current the ideas, the molecular structure, the biochemical pathways, and the pathophysiological value of apoptosis. moreover, regular biochemical and mobile biologic ways to apoptosis examine are defined as a tenet for bench paintings, with medical purposes precise for immune issues, melanoma, ischemia/reperfusion harm, and neuronal degeneration.

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Extra resources for Essentials of Apoptosis. A Guide for Basic and Clinical Research

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Nature 400(6747), 886–891. 125. Knudson, C. , Johnson, G. , and Korsmeyer, S. J. (2001) Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res. 61(2), 659–665. 126. , Chiang, C. , and Yang, E. (2001) BAD/Bcl-xL heterodimerization leads to bypass of G0/G1 arrest. Oncogene 20(33), 4507–4518. 28 Yin et al. The IAPs 29 3 Inhibitors of Apoptosis Proteins Peter Liston, Wai Gin Fong, and Robert G. Korneluk INTRODUCTION The preceding decade has witnessed a genuine revolution in our understanding of the regulation of cell homeostasis in health and disease.

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J. (1996) Bid: A novel BH3 domain-only death agonist. Genes Dev. 10(22), 2859–2869. 30. Oltvai, Z. N. and Korsmeyer, S. J. (1994) Checkpoints of dueling dimers foil death wishes (comment). Cell 79(2), 189–192. 31. , and Reed, J. C. (2001) Bcl-b, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J. Biol. Chem. 276(16), 12481–12484. 32. Hsu, S. , and Hsueh, A. J. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members.

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Essentials of Apoptosis. A Guide for Basic and Clinical Research by Xiao-Ming Yin, Zheng Dong


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