By Sunil K Lal
ISBN-10: 1429468394
ISBN-13: 9781429468398
ISBN-10: 3318013943
ISBN-13: 9783318013948
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Extra info for Emerging viral diseases of Southeast Asia
Sample text
The clinical presentation during hospitalization of these Thai patients is shown in table 1. Chest X-ray at early onset of disease showed lobar and patchy pneumonia in most of the cases and interstitial pneumonia was only found in 2 cases. At late onset, acute respiratory distress syndrome was found in all 12 dead cases, while it was present only in 1 of the 5 survivor cases. In contrast to ordinary human influenza virus infection, H5N1 viruses induce multi-organ failure which may be fatal. Outcomes of the disease in these patients are shown in table 2.
Subbarao K, Shaw MW: Molecular aspects of avian influenza (H5N1) viruses isolated from humans. Rev Med Virol 2000;10:337–348. Li KS, Guan Y, Wang J, et al: Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 2004;430:209–213. Chen H, Smith GJD, Li KS, et al: Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control. Proc Natl Acad Sci USA 2006;103;2845–2850. Matrosovich M, Zhou N, Kawaoka Y, Webster R: The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.
The larger segment, A, encodes a polyprotein of approximately 106 kDa which is autoproteolytically cleaved to form the viral capsid proteins VP2 and VP3, and a nonstructural (NS) protein. Recently, the active residues in the NS protein responsible for processing of the polyprotein have been identified, thus proving that NS represents the viral protease [4]. A 17-kDa (VP5) protein encoded by a second open reading frame (ORF) of segment A which precedes and partially overlaps the polyprotein gene has been detected in virus-infected cells [5].
Emerging viral diseases of Southeast Asia by Sunil K Lal
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