Read e-book online Early Puberty: Latest Findings, Diagnosis, Treatment, PDF

By Claire Bouvattier, Catherine Pienkowski

ISBN-10: 2817805208

ISBN-13: 9782817805207

ISBN-10: 2817805429

ISBN-13: 9782817805429

ISBN-10: 2817805437

ISBN-13: 9782817805436

This e-book specializes in the state-of-the-art in totally greedy precocious puberty and its outcomes, incorporating advances within the parts of endocrinology, genetics, imaging and therapeutics to provide an integral software for all physicians drawn to the most recent advances during this box. The authors current the most recent findings on early puberty in boys and girls. The dynamic technique of maturation is encouraged through many signs and reshapes becoming children’s position inside their environment.

Readers will enjoy the academic price and point of intensity of the person chapters; written via revered specialists and in a self-contained layout, they could even be learn individually to deal with particular interests.

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Additional resources for Early Puberty: Latest Findings, Diagnosis, Treatment, Long-term Outcome

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Proos LA (2009) Growth & development of Indian children adopted in Sweden. Indian Med J Res 130(5):646–650 9. Teilmann G, Petersen JH, Damgaard K, Skakkebaek NE, Jensen TK (2009) Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years. Horm Res 72(4):236–246 10. Choulot JJ, Mechain S, Saint Martin J, Doireau V, Mensire A (1998) Adoption et portage chronique du virus B. Arch Pediatr 5:869–872 11. Le Masne A (1999) Attitude du pédiatre chez l’enfant adopté à l’étranger.

The first biological change demonstrating that the gonadotropic axis is reactivated during puberty is the occurrence of nocturnal LH pulses in children, before entering Tanner stage 2. This reactivation is subclinical. The frequency and amplitude of nocturnal LH pulses increase, and diurnal release peaks are then observed. This pulsatile LH secretion is secondary to the increase in pulsatile GnRH secretion. This biological reactivation occurs earlier in girls than boys. The secretion of testosterone in blood increases shortly after LH, and FSH increases in plasma.

In boys, the first clinical sign of pubertal onset is testicular enlargement, mainly due to cell development within the seminiferous tubules. Yet these are the cells most likely to be affected by chemotherapy, especially alkylating agents, and radiation therapy. In boys treated for malignant tumors with both chemo- and radiotherapy, testicular volume is thus not a good marker for the onset of puberty as the testes may remain small despite significant endogenous testosterone secretion. Only the systematic measure of morning serum testosterone and gonadotropin levels can guide early diagnosis [57], but other signs of pubertal onset must also be observed, particularly the increase in growth velocity.

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Early Puberty: Latest Findings, Diagnosis, Treatment, Long-term Outcome by Claire Bouvattier, Catherine Pienkowski


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