By Siegfried Knasmüller, David M. DeMarini, Ian Johnson, Clarissa Gerhäuser
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Extra info for Chemoprevention of Cancer and DNA Damage by Dietary Factors
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Exp. Biol. , 203: 127–139. McClure, W. R. (1985) Mechanisms and control of transcription initiation in prokaryotes. Ann. Rev. , 54: 171–204. TRANSCRIPTION IN EUKARYOTES 43 RNA polymerases and transcription initiation complexes Nikolov, D. , Halay, E. D. et al. (1995) Crystal structure of a TFIIB–TBP–TATAelement ternary complex. Nature, 377: 119–128. Roeder, R. G. (1996) The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. , 21: 327–335. Travers, A. (1996) Building an initiation machine.
R. (1977) Postembryonic cell lineages of the nematode worm Caenorhabditis elegans. Dev. , 56: 110–156. Genome composition and sequencing Recently, issues of the journals Science and Nature have been devoted to descriptions of the genomes of particular organisms. Specific articles are cited, but others in the same issues are also of interest. For the most complete and up-to-date information, consult the listed Web sites: Yeast (S. , Barrell, B. , Bussey, H. et al. (1996) Life with 6000 genes. Science, 274: 546–567.
As noted in the previous chapter, the extreme conservation through evolution of many elements of the transcription apparatus means that studies on simple eukaryotes can provide valuable insights into the workings of the analogous systems in higher organisms. Large genome problems: why are things so complicated? This is probably a good point at which to try to come up with some sort of justification for the extraordinary complexity of the eukaryotic PIC. Why should something that is achieved with such elegant simplicity (in retrospect) by prokaryotes have attained such monstrous dimensions in even a simple, single-celled eukaryote such as yeast?
Chemoprevention of Cancer and DNA Damage by Dietary Factors by Siegfried Knasmüller, David M. DeMarini, Ian Johnson, Clarissa Gerhäuser
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