By Ying Xu, Juan Cui, David Puett
ISBN-10: 1493913808
ISBN-13: 9781493913800
ISBN-10: 1493913816
ISBN-13: 9781493913817
This publication offers a framework for computational researchers learning the fundamentals of melanoma via comparative analyses of omic information. It discusses how key melanoma pathways will be analyzed and chanced on to derive new insights into the sickness and identifies diagnostic and prognostic markers for melanoma. Chapters clarify the elemental melanoma biology and the way melanoma develops, together with the various power survival routes. The exam of gene-expression styles uncovers commonalities throughout a number of cancers and particular features of person melanoma forms. The authors additionally deal with melanoma as an evolving advanced procedure, discover destiny case stories, and summarize the basic on-line facts assets. melanoma Bioinformatics is designed for practitioners and researchers operating in melanoma learn and bioinformatics. it's also appropriate as a secondary textbook for advanced-level scholars learning laptop technological know-how, biostatistics or biomedicine.
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Additional resources for Cancer Bioinformatics
Sample text
Tumor cells have developed several mechanisms for overcoming the apoptotic pathway including the loss of P53 function (a common alteration in cancer cells) and others that are actively being studied. 4 Enabling Replicative Immortality Located on the ends of chromosomes, telomeres, composed of hexanucleotide repeats, are shortened as cells undergo progressive divisions. In time, after multiple divisions the telomeres become sufficiently shortened that cells are no longer viable, leading to senescence and eventual cell death.
Thus, ATP is constantly being utilized and resynthesized to meet daily needs. For someone who is physically active, the caloric requirement rises dramatically, and consequently ATP biosynthesis must increase as well. 2 J). e. ] Metabolism of carbohydrates, proteins and lipids yields approximately 4 Cal/g, 4 Cal/g and 9 Cal/g, respectively. Thus, per unit weight ingested, lipids provide more than twice the Cal (or energy) than do carbohydrates and proteins; however, we rely on all three for energetic needs, particularly lipids and carbohydrates (and certainly circulating glucose for minute-to-minute cellular needs).
This gene encodes a tyrosine kinase that functions in a cellular growth pathway; the mutation of the gene in the retroviral genome renders the gene product constitutively active, thus the explanation for tumorigenicity in infected chickens. e. a proto-oncogene (also referred to as a cellular oncogene), from the infected bird and incorporated it into its genome. A subsequent mutation in the SRC gene was sufficient to render the protein constitutively active such that proliferation signaling occurred in the absence of proper growth signals.
Cancer Bioinformatics by Ying Xu, Juan Cui, David Puett
by Thomas
4.5