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Alonso Moraga, R. Castro, and E. Diaz Carrillo. 1994. Genotoxicity testing of dif ferent types of beverages in the Drosophila wing somatic mutation and recombination test. Food Chem. Toxicol. 32(5):423-430. , and G. Skidmore. 1987. Compositae dermatitis in childhood. Arch. Dermatol. 123(4):500-502. M. 1996. A 6-year experience with compositae mix. Am. J. Contact Dermat. 7(2):94-99. , J. Breuer, J. Weglewski, and G. Rücker. 1991. , Compositae). Contact Dermat. 24(4):274-280. , E. V egeto, S. Dall’Acqua, et al.

1979). III. Pharmacology and Pharmacokinetics Human Pharmacological Studies No relevant human pharmacological studies were identified. Animal Pharmacological Studies An ethanolic extract of calamus demonstrated immunomodulatory potential by inhibiting proliferation of mitogen- and antigen-stimulated human peripheral blood mononuclear cells. The extract inhibited growth of several mouse and human cell lines (Mehrotra et al. 2003). indb 9 2/13/13 8:15 AM Acorus calamus A Chronic Toxicity the heart included myocardial atrophy, fibrosis, thrombosis, fatty degeneration, and fatty infiltration (Taylor 1981).

Animal Pharmacological Studies No case reports of suspected drug or supplement interactions were identified. The compound isoferulic acid, isolated from Chinese cimicifuga, has been shown to lower plasma glucose in diabetic rats in a dose-dependent manner with effects on plasma glucose observed at doses of 5 mg/kg (intravenous) and higher (Liu et al. 1999). Animal Trials of Drug or Supplement Interactions No animal trials of drug or supplement interactions were identified. In Vitro Pharmacological Studies II.

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