By Claudio Fuganti, Piero Grasselli (auth.), Upendra K. Pandit, Frank C. Alderweireldt (eds.)
In present pondering, Bioorganic Chemistry might be outlined because the zone of chemistry which lies within the border quarter among natural chemistry and biology and which describes and analyzes organic phenomena by way of targeted molecular buildings and molecular mechanisms. This molecular-level view of organic procedures isn't just necessary to their fuller realizing but additionally serves because the platform for the applying of the foundations of such procedures to parts of wellbeing and fitness care and expertise. the target of the ASI workshop on " Bioorganic Chemistry in Healthcare and Technology", held within the Hengelhoef Congress Centre in Houthalen-Helchteren, Belgium, from September 18-21, 1990, was once to assemble lots of the foreign specialists within the box to debate the present advancements and new tendencies in bioorganic chemistry, specially with regards to the chosen topic. The publication provides nineteen invited plenary and consultation lectures and eighteen posters. those hide components of (i) molecular layout of healing and agronomical brokers established npon mechanistic reason or drug-receptor interactions, (ii) creation of drugs of business price through mixed natural chemical and bio-chemical methodologies, (iii) primary reviews at the molecular mechanisms of enzymes and (iv) the evolution of conceptually new molecular platforms that are programmed to execute particular reputation and/or catalytic services. An abstracted model of the plenary dialogue held on the finish of the workshop is usually integrated. We think convinced that the subject material of this ebook could be of curiosity to a vast staff of chemists engaged in educational or commercial research.
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The exposed and interlocked Thr-Gly p-turn appears to be a highly conserved structural motif of TIM. Thus, it is of interest to examine whether the exposed Thr-Gly p-turn is a unique structural motif of the dimeric TIM enzyme or whether it is also found in other protein structures. A protocol of related searches for primary and secondary structure information in ROPDB (ROche Protein structure Data Base)1,2 is reproduced in Figure 6. Again, relevant information is readily gathered. A number of occurrencies of Thr-Gly or Ser-Gly p-turns are uncovered in a variety of proteins and enzymes.
V. Ganin, Yu. A. F. L. Kamalov, 'Structure of macrocyc1ic phthalic acid diamides', Zh. Strukt. Khim 23:103 (1982). 18. F. K. Winkler and J. D. Dunitz, 'Medium-Ring Compounds. XXVII. Caprinolactam Hemihydrochloride', Acta Cryst. B31:286 (1975). 19. M. B. Hossain and D. van der Helm, 'Conformation and Crystal Structures of Two Cyc1oisomeric Hexapeptides: cyc1o-(L-Alanyl-Lalanylglycylglycyl-L-alanylglycyl) Monohydrate (I) and cyc1o-(LAlanyl-L-alanylglycyl-L-alanylglycylglycyl) Dihydrate (II)', J. Am.
A protocol of related searches for primary and secondary structure information in ROPDB (ROche Protein structure Data Base)1,2 is reproduced in Figure 6. Again, relevant information is readily gathered. A number of occurrencies of Thr-Gly or Ser-Gly p-turns are uncovered in a variety of proteins and enzymes. The observation that this structural motif is also found well exposed on the surface of some antibodies 14 and viral coat proteins 15 indicates interesting opportunities for further potential applications of cyclic Thr-Gly containing loop analogs.
Bioorganic Chemistry in Healthcare and Technology by Claudio Fuganti, Piero Grasselli (auth.), Upendra K. Pandit, Frank C. Alderweireldt (eds.)